DEC 16, 2021 10:05 AM PST

Could Stem Cells Cure Type 1 Diabetes?

WRITTEN BY: Alexandria Bass

For people living with chronic diseases like Type 1 diabetes, the word "cure" sounds too good to be true. In fact, before 1922 when insulin was discovered, Type 1 diabetes was a death sentence. This form of diabetes is less common and appears at an earlier age than Type 2 diabetes with the body producing antibodies that attack the insulin-producing cells of the pancreas. Destruction of these cells leads to hyperglycemia and causes symptoms of increased thirst, increased urination with sugar present in the urine, blurred vision, and weight loss despite extreme hunger. Because the body cannot use sugar without insulin, it begins to break down fat for energy in the form of ketones. When too many ketones flood the blood, it becomes too acidic, which can lead to coma and death. Today, an estimated 1.5 million Americans are living with the challenges of Type 1 diabetes.

Dr. Melton, a Type 1 diabetes researcher and Harvard University biologist inspired by his two kids who both have the disease, partnered with Dr. Altshuler, a Harvard professor and chief scientific officer at Vertex Pharmaceuticals, to develop a new treatment for diabetes using stem cells. With this treatment, patients receive an infusion of cells grown from stem cells that now resemble the insulin-producing cells of the pancreas. 

Mr. Shelton, the first patient to enroll in Vertex Pharmaceutical's clinical trial for the treatment, received the infusion and now has normal blood sugar readings without taking insulin. Insulin injections can lead to hypoglycemia, which itself can cause coma and death, and is a particularly worrisome side effect of insulin since it can happen without warning while patients are asleep. Researchers are awaiting results over the long term, but Mr. Shelton may become the first person to be cured of Type 1 diabetes with this new treatment. Previously, the closest thing to a cure was a pancreas transplant, but this was found to be impractical because of the limited number of available transplants relative to the number of Type 1 diabetes patients.

One of the downsides to this new therapy, just like with pancreas transplants, is the need for immunosuppressive drugs to avoid rejection of the stem cells since, after all, they are foreign. How long the beneficial effects on blood sugar last, and whether or not there is a need for repeated treatments, is unknown at this time. Vertex Pharmaceuticals has also not yet revealed the price of the new therapy and has been scrutinized in the past for hefty pharmaceutical price tags. 

Sources: The New York Times, StatPearls, J Community Hosp Intern Med Perspect
 

About the Author
BA in Psychology
Alexandria (Alex) is a freelance science writer with a passion for educating the public on health issues. Her other professional experience includes working as a speech-language pathologist in health care, a research assistant in a food science laboratory, and an English teaching assistant in Spain. In her spare time, Alex enjoys cycling, lap swimming, jogging, and reading.
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