JAN 11, 2016 1:19 PM PST

Hormone Extends Lifespan by Strengthening Immune System

WRITTEN BY: Julianne Chiaet
Given a choice, most of us would choose to never get sick and live forever. Now, researchers have uncovered how a hormone might help us achieve that goal. 
 
Life-extending hormone bolsters the body's immune function.
Researchers at Yale School of Medicine found that boosting levels of the hormone FGF21 guards against the natural loss of immune function that comes with age.

Produced in the liver, FGF21 increases when calories are restricted. The increase triggers the body to go into fat-burning mode; allowing the body to fuel itself with stored fat. Previous studies have found that raised levels of FGF21 extend the lifespan of mice by 40 percent. 

The researchers studied the thymus in mice with both increased and decreased levels of hormone FGF21. The thymus is a lymphoid organ that produces T cells for the immune system. As a person ages, the thymus degenerates and eventually becomes difficult to identify. The organ shrinks, becomes fatty, and loses its ability to produce new T cells. The loss of T cells causes an increased risk of infections and certain cancers.

The study showed that raised FGF21 levels protected the thymus from age-related fatty degeneration and heightened the thymus’ ability to produce T cells. Decreased levels of FGF21 accelerated the thymus' degeneration. 

The research could be used in the future to improve immune function for the elderly, obese people, and those suffering from illnesses, such as type-2 diabetes. Further research needs to be done to understand the mechanisms behind FGF21 that protect the thymus from aging. "We will also look to developing a way to mimic calorie restriction to enhance immune function without actually reducing caloric intake,” said study author and immunobiologist Vishwa Deep Dixit.

The study was published online in the Proceedings of the National Academy of Sciences on January 11, 2016. 

Sources : Yale University press release via EurekAlert!, PNAS journal studyResveratrol News
About the Author
  • Julianne (@JuliChiaet) covers health and medicine for LabRoots. Her work has been published in The Daily Beast, Scientific American, and MailOnline. While primarily a science journalist, she has also covered culture and Japanese organized crime. She is the New York Board Representative for the Asian American Journalists Association (AAJA). • To read more of her writing, or to send her a message, go to Jchiaet.com
You May Also Like
DEC 25, 2020
Immunology
A High-Fat Diet Starves Immune Cells, Tumor Growth Goes Unchecked
DEC 25, 2020
A High-Fat Diet Starves Immune Cells, Tumor Growth Goes Unchecked
  Sitting down to enjoy an indulgent Christmas feast? A recent study in mice by Harvard Medicine scientists found t ...
DEC 30, 2020
Drug Discovery & Development
Gene Therapy Cures Mice of Deafness
DEC 30, 2020
Gene Therapy Cures Mice of Deafness
Currently, around half a billion people suffer from hearing loss around the world. In about half of these cases, genetic ...
JAN 05, 2021
Cell & Molecular Biology
Brown Fat Appears to Protect Against Disease
JAN 05, 2021
Brown Fat Appears to Protect Against Disease
Not all fat is the same. White fat is what we're usually thinking of when we think of flabby tissue that stores excess c ...
JAN 11, 2021
Genetics & Genomics
Treating Progeria With a CRISPR Technique
JAN 11, 2021
Treating Progeria With a CRISPR Technique
Hutchinson-Gilford progeria syndrome is a rare disorder that impacts around 400 people in the world. Many people have he ...
JAN 11, 2021
Immunology
Can Immune cells contribute to Lung Diseases Severity?!
JAN 11, 2021
Can Immune cells contribute to Lung Diseases Severity?!
Macrophages are a type of immune cell that can detect and destruct bacteria, viruses, and harmful materials. They a ...
JAN 23, 2021
Microbiology
Host Vouchering & How Can It Improve Pandemic Response
JAN 23, 2021
Host Vouchering & How Can It Improve Pandemic Response
About a year ago, I wrote about the virus that would come to be known as SARS-CoV-2 for the first time. And while we've ...
Loading Comments...