MAY 02, 2017 7:44 PM PDT

Some blood types associated with higher risk of heart disease

WRITTEN BY: Kara Marker

An intriguing link between people with non-O blood groups and a higher risk of adverse cardiac events is the subject of a new study from the European Society of Cardiology. Non-O blood groups, I.E. A, B, or AB blood groups have been associated with risk of heart problems in the past, but the newest study provides clearer evidence.

Source: Biology Questions and Answers

Past research suggesting this phenomenon came from case-control studies with not a lot of evidence, but the the present study included a meta-analysis of multiple prospective studies comparing O and non-O blood groups looking for any difference in risk for cardiovascular events: myocardial infarction AKA heart attack, coronary artery disease, ischaemic heart disease, heart failure and cardiovascular mortality.

Of nearly one-and-a-half million study subjects, an analysis of coronary and combined cardiovascular events included around 7-800,000 with a non-O blood group and 500,000 with an O blood group. Odds ratios for both analyses showed carriers of a non-O blood group to be at a higher risk of heart disease.

"We demonstrate that having a non-O blood group is associated with a 9% increased risk of coronary events and a 9% increased risk of cardiovascular events, especially myocardial infarction," explained lead author Tessa Kole.

Nine percent may not seem like a lot, studies like Kole’s at the very least shine a light on this connection for future study. In the mean time, researchers have a few guesses as to what factors could be influencing the increased risk of cardiac events for non-O blood groups.

  • Greater concentrations of von Willebrand factor, a blood clotting protein associated with thrombotic events

  • Higher cholesterol, which is common in non-O blood group carriers, particularly in the A blood group
  • Galectin-3, a biomarker linked to inflammation and poor health outcomes for heart failure patients and which is also especially high in non-O blood group

More research is necessary to understand the connection completely, but for now, Kole recommends that “blood group should be considered in risk assessment for cardiovascular prevention, together with cholesterol, age, sex and systolic blood pressure. We need further studies to validate if the excess cardiovascular risk in non-O blood group carriers may be amenable to treatment."

Source: Mayo Medical Laboratories, National Health Service, European Heart Society

About the Author
  • I am a scientific journalist and enthusiast, especially in the realm of biomedicine. I am passionate about conveying the truth in scientific phenomena and subsequently improving health and public awareness. Sometimes scientific research needs a translator to effectively communicate the scientific jargon present in significant findings. I plan to be that translating communicator, and I hope to decrease the spread of misrepresented scientific phenomena! Check out my science blog: ScienceKara.com.
You May Also Like
JUN 04, 2020
Immunology
JUN 04, 2020
Tissue Stiffness Regulates Immune Responses
  Cells are remarkably sensitive to the mechanical properties of their environment, changing their behavior as a re ...
JUN 07, 2020
Microbiology
JUN 07, 2020
Infants Exposed to Antibiotics are at Greater Risk for Childhood Obesity
The human gut hosts a huge community of microbes, potentially even before birth, which helps us digest and absorb nutrie ...
JUN 09, 2020
Neuroscience
JUN 09, 2020
Researchers Discover the Brain Cells that Control Appetite
Researchers from the University of Warwick in England have found that specific cells in the brain can both stimulate and ...
JUN 10, 2020
Cardiology
JUN 10, 2020
Aerobic Fitness Levels Associated with Weight Loss
According to a recent study at the American College of Physicians (ACP) Internal Medicine Meeting, improvements in aerob ...
JUN 18, 2020
Health & Medicine
JUN 18, 2020
People Taking Medicinal Cannabis Report Greater Well-Being
Legalization of medicinal cannabis is now fairly widespread, yet there's been a paucity of data collected on patient exp ...
JUN 30, 2020
Health & Medicine
JUN 30, 2020
UK Loosens Regulation on Prescription CBD for Epilepsy
Epidyolex-the epilepsy drug that contains the non-psychoactive cannabis chemical cannabidiol, or CBD-has been changed fr ...
Loading Comments...