DEC 19, 2018 06:51 PM PST

UTI Infection Becoming a Common Reoccurrence?

A Urinary tract infection (UTI) is one reason many patients take a trip to visit their physician. Upon clearing of the infection, some individuals find that the annoyance has returned and rather quickly, leaving them questioning the effectiveness of the treatment. In a recent study published in the scientific journal known as PLOS Pathogens, a team of researchers sheds light on what could be going on.

A urinary tract infection is an infection in any part of your urinary system —  kidneys, ureters, bladder, and urethra. Most infections involve the lower urinary tract — the bladder and the urethra.

Women are at higher risk of developing a UTI than are men. Infection limited to your bladder can be painful and annoying. However, serious consequences can occur if a UTI spreads to your kidneys.

Urinary tract infections are widespread and can be highly recurrent, with 1–2% of women suffering from six or more frequent episodes per year. The high incidence of recurrent UTI, including recurrent infections caused by the same bacterial strain that produced the first infection, suggests that at least some women do not mount a protective adaptive immune response to UTI.

Many patients suffer from highly recurrent urinary tract infections caused by Escherichia coli, which are genetically diverse bacteria. Recurrent episodes are often caused by the same E. coli strain that created the first infection, suggesting that some patients may not develop a protective immune response.

The researchers, making use of bladder infected mouse models, discover that two E. coli strains behave differently. One strain, known as UTI89, infects the bladder indefinitely, whereas another strain called CFT073 is cleared within eight weeks.

Interestingly, mice which had already been exposed to CFT073 and treated with antibiotics were henceforth protected from reinfection, however, remained susceptible to UTI89 infection. In contrast to this finding, mice with a UTI89 infection and antibiotics were susceptible to recurrent UTI when challenged with either strain.

“We found that depleting T cells, immune cells important for developing protection against infection prevented mice from clearing their CFT073 infections and made them susceptible to recurrent CFT073 UTI. Thus, while infection with one E. coli strain could trigger a protective immune response, another strain sidestepped this response” shares authors of the publication.

“Our findings demonstrate the complex interplay between the broad genetic diversity of UPEC and the host innate and adaptive immune responses during UTI. A better understanding of these host-pathogen interactions is urgently needed for effective drug and vaccine development in the era of increasing antibiotic resistance,” shares the authors of the study.

The findings to this study shed new light on immune responses to UTI and may be essential for drug and vaccine development.

Sources: PLOS Pathogen, Mayo Clinic, YouTube

About the Author
You May Also Like
NOV 15, 2019
Genetics & Genomics
NOV 15, 2019
Increasing Evidence Shows Narcolepsy is an Autoimmune Illness
Narcolepsy is a chronic sleep disorder impacting as many as 200,000 people in the US, and is thought to often go undiagnosed....
NOV 15, 2019
Drug Discovery & Development
NOV 15, 2019
Aspirin Combats Tuberculosis
Tuberculosis is a global infection far from being eradicated. It currently infects more than 1,400 people per year in Australia. The deadliest form and exp...
NOV 15, 2019
Health & Medicine
NOV 15, 2019
Why does the flu virus thrive during winter?
If you’re one of the nearly 7 million people who suffered from influenza last season, you might be curious why the virus hits so much during winter m...
NOV 15, 2019
Immunology
NOV 15, 2019
New Research In Reversing Deafness
Hair cells inside the human ear are responsible for sensing and relaying sound to the brain.  In all mammals except humans, these cells can regenerate...
NOV 15, 2019
Immunology
NOV 15, 2019
Coffee Bean Extracts for Fat-induced Inflammation
One man’s coffee trash is another man’s solution for addressing chronic inflammation. A new Food and Chemical Toxicology study illustrates the ...
NOV 15, 2019
Immunology
NOV 15, 2019
Allergy Shots May Work for Kids with Pollen Food Allergy Syndrome
It’s not common for young children to develop pollen food allergy syndrome (PFAS), but for those that do, there’s not too much parents can do o...
Loading Comments...