NOV 25, 2015 04:15 PM PST

The Flu Probably Won't Kill You, But This Side Effect Might

WRITTEN BY: Kara Marker
The H1N1 influenza caused a massive panic in 2009, and scientists may have an answer for why this strain of flu is so much deadlier. A gene mutation making people susceptible to a "deadly hyperinflammatory disorder" was investigated in a study conducted by scientists from Cincinnati Children's Hospital Medical Center, and the findings were recently published in The Journal of Infectious Diseases.

Everybody needs cytokines, macrophages, and T cells to fight off infections, but a little bit of inflammation goes a long way. In a study of 16 patients who died while infected with H1N1, 44 percent of cases were connected to a condition called reactive hemophagocytic lymphohistiocytosis (rHLH). Tissue samples were taken from these patients, and full genetic screening was performed on the samples. HLH gene mutations render people susceptible to developing severe inflammatory reactions when infected with a pathogen. 

The more a pathogen naturally triggers inflammation as the body responds to fight off infection, the more likely someone with this gene mutation is to experience deadly inflammation. H1N1 stimulates more inflammation than other strains of the flu, so this could explain why the pandemic in 2009 was so deadly. 

"H1N1 has become part of the viral mix for the annual flu season and preventative vaccine", Cincinnati scientists said.

Patients experiencing the effects of this hyperinflammatory condition have overwhelming inflammation damages to their vital internal organs, causing death. A part of this reaction comes from macrophage activation syndrome (MAS), a complication normally associated with autoimmune disease that causes "uncontrolled proliferation of T lymphocytes and well-differentiated macrophages" (Medscape). 81 percent of the tissue samples from the study were associated with MAS. 

The results of this study cause scientists to think about screening options for this genetic mutation, especially in children. Another option to be investigated is immunosuppressive therapy. The right balance must be met for this treatment to be effective, enough for lethal hyperinflammation to be stopped, but not too much to totally stop inflammation needed to ward off infection. 

Watch the following video to learn more about HLH.
Source: EurekAlert


 
About the Author
  • I am a scientific journalist and enthusiast, especially in the realm of biomedicine. I am passionate about conveying the truth in scientific phenomena and subsequently improving health and public awareness. Sometimes scientific research needs a translator to effectively communicate the scientific jargon present in significant findings. I plan to be that translating communicator, and I hope to decrease the spread of misrepresented scientific phenomena! Check out my science blog: ScienceKara.com.
You May Also Like
SEP 17, 2019
Immunology
SEP 17, 2019
Heating Up on the Flu
Climate change may affect the future of vaccinations and nutrition....
SEP 17, 2019
Immunology
SEP 17, 2019
Silent Inflammation, the Silent Problem
People who have chronic inflammation in middle-age may develop problems with thinking and memory...
SEP 17, 2019
Health & Medicine
SEP 17, 2019
Why does the flu virus thrive during winter?
If you’re one of the nearly 7 million people who suffered from influenza last season, you might be curious why the virus hits so much during winter m...
SEP 17, 2019
Health & Medicine
SEP 17, 2019
The Race To Preserve The Microbiome
It is well established that the microbiome is essential for metabolism and digestion. The gut bacteria that make up the microbiome are also believed to pla...
SEP 17, 2019
Immunology
SEP 17, 2019
AI Not Ready To Predict Acute Kidney Injury
An international group of scientists from the U.S. and U.K. published new research in Nature about the effectiveness of AI in predicting Acute Kidney Injur...
SEP 17, 2019
Drug Discovery
SEP 17, 2019
The Three Drugs that Reverse Biological Aging
In the last 100 years, life expectancy in the US has risen from 55 years until 79 (Roser: 2019). And with the continuous development of medicine and scie...
Loading Comments...