NOV 28, 2015 06:11 AM PST

A Combination of Drugs and Immunotherapy To Treat Breast Cancer

WRITTEN BY: Kara Marker
The American Cancer Society predicts that over 40,000 women will die from breast cancer this year, and that's just in the United States. As motivated as ever, scientists from the University of Basel have developed a novel treatment plan to target breast cancer. 

With their results published in Science Translational Medicine, the team from Switzerland successfully created an "antibody-drug conjugate" (ADC) to pair with immunotherapy to attack cancerous cells. The ADC stimulates the immune system to bind to and kill tumor cells as they grow. 

The basis of the ADC mechanism comes from an observation of breast cell growth factors. About one-fifth of breast cancer patients show increased levels of human growth factor receptor 2 (HER2) on their tumor cell surfaces (breastcancer.org). Normal breast cell growth is harmless, but when too many HER2 genes are stimulating growth, cancer occurs. The ADC developed by the scientists from the University of Basel blocks the action of these malfunctioning receptors while simultaneously releasing cytotoxic chemicals that enter the tumor cell and instigate cell death.

In a study of mouse breast cancer models, the team combined ADC administration with immunotherapy treatments. By administering complementary antibodies to activate T lymphocytes, immunotherapy helps "reroute" the body's natural "immunoregulatory checkpoints" to ensure the right immune cells are being activated to fight the cancer. Without pairing immunotherapy with ADC treatment, T cell activation would not be as helpful. 

Combination therapy is a bright, new perspective for breast cancer treatment, and doctors like lead author Philipp Muller believe that "antibody-drug conjugates are suitable for use in a combination therapy."

Watch the following video to hear more about ADCs in detail.
Source: University of Basel
About the Author
  • I am a scientific journalist and enthusiast, especially in the realm of biomedicine. I am passionate about conveying the truth in scientific phenomena and subsequently improving health and public awareness. Sometimes scientific research needs a translator to effectively communicate the scientific jargon present in significant findings. I plan to be that translating communicator, and I hope to decrease the spread of misrepresented scientific phenomena! Check out my science blog: ScienceKara.com.
You May Also Like
SEP 17, 2019
Health & Medicine
SEP 17, 2019
The Role of the Gut-Lung Axis in the Development of Tuberculosis
Observations of the human microbiota date back as far as the 1680s when Antonie van Leeuwenhoek noted significant differences in the types of bacteria from...
SEP 17, 2019
Immunology
SEP 17, 2019
Why Does My Throat Hurt Again
Scientists are uncovering the mechanisms behind recurring cases of step throat...
SEP 17, 2019
Health & Medicine
SEP 17, 2019
A Second Patient Cured of HIV: Are We Close to a Cure for Everyone Infected?
There is a consensus that the first HIV infection occurred in the 1920s in Kinshasa, the Democratic Republic of Congo when it was passed to human...
SEP 17, 2019
Health & Medicine
SEP 17, 2019
Dietary Cholesterol and Its Impact on Autoimmune and Infectious Disease Processes
There has been a great deal of media coverage and controversy over the role of diet on disease processes such as autoimmunity and infection. Can dietary ch...
SEP 17, 2019
Health & Medicine
SEP 17, 2019
Can a Low-Carb Diet Treat Osteoarthritis?
A pilot study suggests it might. Researchers at the University of Alabama, Birmingham, found that a low-carbohydrate diet was able to reduce pain intensity...
SEP 17, 2019
Health & Medicine
SEP 17, 2019
Drug-resistant Candida Auris is Spreading
A drug-resistant fungal yeast, Candida auris, is spreading throughout hospitals worldwide. Deemed “an urgent threat” by the Center for Disease...
Loading Comments...