JAN 20, 2016 1:49 PM PST

When It Seems Like You're the Only One Who Gets Sick

WRITTEN BY: Kara Marker
The whole family ate the same seafood last night, yet only two out of the six got sick. What gives?
 
In a new study from Duke Health, scientists have identified 29 innate immunity-related genes that can predict which members of a group are less and more likely than others to become infected with a circulating pathogen.
 
Out of 30 healthy participants who were exposed to Escherichia coli, a common cause of food poisoning and traveler’s diarrhea, six experienced extreme symptoms and six appeared to be unaffected. Senior author of the study published in the Journal of Infectious Diseases, Ephraim Taslik, MD, PhD, and his team closely analyzed the genetic differences between these two groups.
 
 

Tsalik and his team used blood samples to look for key changes in gene expression, and the 29 immune-related genes they found to be involved seemed to be predictive of how each host would respond to an E. coli infection.
 
"Within each group, there were changes in the patients' gene expression patterns happening throughout the experiment," Tsalik said.
 
The six participants whose gene expression boosted their immune system during the experiment are not decidedly protected against all future infections, but the Duke scientists have clearly identified the genes that increased the participants’ chances of staying healthy. The impact of environmental influences, stress, and diversity of the microbiome also plays a big role in decreasing or increasing someone’s risk for developing an infection.
 
Going forward, Tsalik plans to see how the same genes boost the immune response to microorganisms other than E. coli, like viruses and other types of bacteria. He said he will be looking for new ways to boost the immune system, depending on how gene expression changes in different cases of infection.
 
Genes of the innate immune system


Source: Duke Health
 
 
About the Author
  • I am a scientific journalist and enthusiast, especially in the realm of biomedicine. I am passionate about conveying the truth in scientific phenomena and subsequently improving health and public awareness. Sometimes scientific research needs a translator to effectively communicate the scientific jargon present in significant findings. I plan to be that translating communicator, and I hope to decrease the spread of misrepresented scientific phenomena! Check out my science blog: ScienceKara.com.
You May Also Like
AUG 04, 2020
Microbiology
Why the Brain Parasite You May Carry Isn't a Problem
AUG 04, 2020
Why the Brain Parasite You May Carry Isn't a Problem
Toxoplasma gondii is a parasite transmitted by cats and contaminated meat, and it's thought that over 30 million America ...
AUG 05, 2020
Immunology
Intercepting Cancer Cells Before They Can Dodge the Immune System
AUG 05, 2020
Intercepting Cancer Cells Before They Can Dodge the Immune System
The battle that naturally occurs between the body’s immune system and cancerous cells is one that scientists have ...
AUG 27, 2020
Immunology
A Seaweed-Inspired Shuttle for Delivering a Stem Cell Cargo
AUG 27, 2020
A Seaweed-Inspired Shuttle for Delivering a Stem Cell Cargo
  Living medicines in the form of stem cell therapies have immense potential for their ability to regenerate and he ...
SEP 03, 2020
Immunology
A Low-Cost COVID-19 Treatment, Made in Horses
SEP 03, 2020
A Low-Cost COVID-19 Treatment, Made in Horses
Researchers in Costa Rica are turning to horses as an unlikely source of potential therapeutic antibodies against COVID- ...
OCT 12, 2020
Drug Discovery & Development
Researchers Solve Key Problem for Cancer Immunotherapy
OCT 12, 2020
Researchers Solve Key Problem for Cancer Immunotherapy
Cancer immunotherapies are becoming increasingly promising as a standard-of-care treatment. However, despite their promi ...
OCT 21, 2020
Drug Discovery & Development
Experimental Vaccine Shows Promise in Halting Alzheimer's
OCT 21, 2020
Experimental Vaccine Shows Promise in Halting Alzheimer's
In a preclinical study, researchers from the Univerity of South Florida have found that a vaccine that targets neurotoxi ...
Loading Comments...