JAN 20, 2016 1:49 PM PST

When It Seems Like You're the Only One Who Gets Sick

WRITTEN BY: Kara Marker
The whole family ate the same seafood last night, yet only two out of the six got sick. What gives?
 
In a new study from Duke Health, scientists have identified 29 innate immunity-related genes that can predict which members of a group are less and more likely than others to become infected with a circulating pathogen.
 
Out of 30 healthy participants who were exposed to Escherichia coli, a common cause of food poisoning and traveler’s diarrhea, six experienced extreme symptoms and six appeared to be unaffected. Senior author of the study published in the Journal of Infectious Diseases, Ephraim Taslik, MD, PhD, and his team closely analyzed the genetic differences between these two groups.
 
 

Tsalik and his team used blood samples to look for key changes in gene expression, and the 29 immune-related genes they found to be involved seemed to be predictive of how each host would respond to an E. coli infection.
 
"Within each group, there were changes in the patients' gene expression patterns happening throughout the experiment," Tsalik said.
 
The six participants whose gene expression boosted their immune system during the experiment are not decidedly protected against all future infections, but the Duke scientists have clearly identified the genes that increased the participants’ chances of staying healthy. The impact of environmental influences, stress, and diversity of the microbiome also plays a big role in decreasing or increasing someone’s risk for developing an infection.
 
Going forward, Tsalik plans to see how the same genes boost the immune response to microorganisms other than E. coli, like viruses and other types of bacteria. He said he will be looking for new ways to boost the immune system, depending on how gene expression changes in different cases of infection.
 
Genes of the innate immune system


Source: Duke Health
 
 
About the Author
  • I am a scientific journalist and enthusiast, especially in the realm of biomedicine. I am passionate about conveying the truth in scientific phenomena and subsequently improving health and public awareness. Sometimes scientific research needs a translator to effectively communicate the scientific jargon present in significant findings. I plan to be that translating communicator, and I hope to decrease the spread of misrepresented scientific phenomena! Check out my science blog: ScienceKara.com.
You May Also Like
AUG 01, 2019
Cancer
AUG 01, 2019
How cancer tricks our immune systems
Research published yesterday in Nature details the finding of a new “Don’t eat me” signal that cancers use to hide from the body’s ...
AUG 17, 2019
Cell & Molecular Biology
AUG 17, 2019
How Neutrophils are Involved in Gallstone Formation
Gallstones form in the gallbladder, and can be as tiny as a grain of sand or as big as a golf ball....
OCT 12, 2019
Immunology
OCT 12, 2019
Treating Alzheimer's? Target Microglia
The body’s own immune cells may be the common denominator in Alzheimer’s disease. In a new study of the relationship between microglia, tau pro...
JAN 28, 2020
Immunology
JAN 28, 2020
Infectious Parasite Manipulates the Immune System to Survive
Toxoplasma gondii suppresses the immune system of the hosts it infects – human or otherwise – just enough to survive, thrive, and move on to mo...
FEB 07, 2020
Neuroscience
FEB 07, 2020
Eating Fruits and Vegetables May Lower Alzheimer's Risk
New research has found that flavonols, a large class of compounds present in many fruits and vegetables, may be linked to a lower risk of developing Alzhei...
FEB 21, 2020
Drug Discovery & Development
FEB 21, 2020
New Antibiotics Found Using AI Technology
Using AI, researchers at MIT have found a powerful new antibiotic capable of killing some of the most dangerous drug-resistant bacteria known to man. ...
Loading Comments...