MAR 04, 2016 2:34 PM PST

What puts children at a greater risk for allergies?

WRITTEN BY: Kara Marker
All food allergies are not created equal. In fact, researchers from the University of Southampton set out to prove just that. In a unique new study, and with 1140 pregnant women as participants, scientists showed both the prevalence of two different types of allergies and the different factors that increase the risk of developing these allergies.

If parents suspect their child might have a food hypersensitivity, they could request a blood test from their doctor to look for immunoglobulin E (IgE) in the blood. IgE is an antibody with connections to allergies reactions and some allergies are IgE-mediated, but some are not. Therefore, a negative IgE blood test wouldn’t completely clear a child of having an allergy.
The eight foods that account for 90% of food allergic reactions in the U.S.

“These tests are only useful for IgE mediated food reactions and therefore are not useful in diagnosing non IgE mediated food allergies,” explained senior research fellow Dr. Kate Grimshaw. “IgE mediated and non-IgE mediated should be considered as two separate conditions and treated accordingly.”

IgE-mediated allergies and non-IgE mediated allergies differ in a few different ways, the researchers found. They observed their 1140 participants throughout their pregnancies, and after each child’s birth until they were two years old. First, IgE-mediated allergies usually cause skin rashes, vomiting, or respiratory issues. However, they can also cause life-threatening reactions as well. In contrast, non-IgE mediated allergies usually consist of mild stomach irritation, occurring between four and 28 hours after ingesting the food. 

The scientists also found that these two different types of food hypersensitivities are associated with different risk factors. Egg and peanut allergies, most often occurring as IgE-mediated hypersensitivities, are worse when in conjunction with eczema or rhinitis.

“Possibly due to a certain gene defect that prevents the skin barrier from forming correctly, leading to possible exposure of the immune system to allergens,” Grimshaw explained.

On the other hand, milk allergies, usually non-IgE mediated, proved to be worse for children in household with pets. In addition, the scientists made a connection between non-IgE mediated allergies and the age at which mothers starting feeding their children solid food. 

Grimshaw, whose study was published in the journal Clinical and Translational Allergy, also had an explanation for this result. 

“Pet ownership may increase the likelihood of gut reactions to food, perhaps by altering the gut flora, which can affect how the digestive system works.”

Luckily, the scientists also observed that a healthy diet helps to reduce the severity of both types of allergies. This is likely due to the disease-preventing and immune-boosting characteristics of the nutrients in fruits and vegetables.

Scientists from the University of Southampton and others will continue to investigate childhood allergies, but for now, knowing the risks and remedies will help to lessen the severity of both types of hypersensitivities.

Source: University of Southampton
About the Author
  • I am a scientific journalist and enthusiast, especially in the realm of biomedicine. I am passionate about conveying the truth in scientific phenomena and subsequently improving health and public awareness. Sometimes scientific research needs a translator to effectively communicate the scientific jargon present in significant findings. I plan to be that translating communicator, and I hope to decrease the spread of misrepresented scientific phenomena! Check out my science blog:
You May Also Like
AUG 17, 2019
Cell & Molecular Biology
AUG 17, 2019
How Neutrophils are Involved in Gallstone Formation
Gallstones form in the gallbladder, and can be as tiny as a grain of sand or as big as a golf ball....
AUG 23, 2019
AUG 23, 2019
Making Opioids Safer
The opioid crisis results in 130 American deaths every day, and both prescribed and synthetic opioids are at the core of the epidemic.  Any other drug...
SEP 07, 2019
SEP 07, 2019
A New Way To Fight Severe Peanut Allergies
Dr. Sandra Lin explains how SLIT is currently being used to treat allergies other than peanuts.    Over 1 million U.S. children have an allergy t...
OCT 13, 2019
OCT 13, 2019
Molecule in Human Breast Milk Can Fight Microbial Pathogens
Now a team of scientists has found a molecule in human breast milk that may reduce the risk of illness and disease....
NOV 10, 2019
Drug Discovery & Development
NOV 10, 2019
Promising Results for New Vaccine Against Dengue Fever
Dengue fever is an illness transmitted by mosquito bites. Affecting around 390 million people per year, if left untreated, its mortality rate is 20%. Altho...
NOV 11, 2019
NOV 11, 2019
Suicidal Mitochondria Responsible for ALS
Scientists at Northwestern University have dicovered a new mechanism in the brain that may be responsable for the early stages of neurodegeneration seen in...
Loading Comments...