MAY 03, 2016 2:08 PM PDT

Salt-Inducible Kinase Inhibitors Reduce Inflammation

WRITTEN BY: Kara Marker
In a new study published in the Journal of Leukocyte Biology, researchers from the University of Geneva discovered a new way to reduce inflammation associated with autoimmune diseases like Crohn’s disease, arthritis, and psoriasis. Salt-inducible kinase (SIK) activity is involved in multiple body processes, but this study shows that inhibiting these enzymes in specific cases could reduce the impact of chronic inflammation.
 

Crohn’s disease (CD) was first described in 1932 as an inflammatory bowel disease characterized by chronic inflammation of the gastrointestinal (GI) tract. CD usually occurs at the end of the ileum and the beginning of the large intestine, affecting the entire thickness of the GI tract wall. Patches of diseased intestine are also common, and patients diagnosed with CD often experience persistent diarrhea, rectal bleeding, abdominal pain, and constipation. Scientists do not know much more about the cause of CD other than connections to heredity, genetic mutations, and environmental factors.

Arthritis, on the other hand, is the leading cause of disability in America, characterized by a spectrum of joint diseases that appear in more than 100 different types and affect 50 million adults. Psoriasis is another autoimmune disease that causes patches of abnormal skin to appear, usually on the elbows, knees or scalp. Psoriasis is not contagious, and there are also several types: Different types: plaque psoriasis (most common), guttate, inverse, pustular, and erythrodermic (most severe).

In their study of two “structurally unrelated” inhibitors of SIK activity, researchers performed genetic interference (RNAi) tests to see what impact there would be on inflammation. They found that inhibiting salt-inducible kinase halts proinflammatory cytokine production and increases anti-inflammatory cytokine secretion by cultured human myeloid cells: monocytes, macrophages, and dendritic cells.

The researchers saw SIK-inhibitors resolving inflammation by preventing the interaction of SIK with TLR signaling. Usually this signaling limits the production of macrophages that produce interleukin-10, an anti-inflammatory molecule, and reduce levels of proinflammatory cytokine interleukin-12 and others.

"This work has the potential to add a new class of therapeutics for inflammatory disorders that could be used in combination with other distinct therapies in hard-to-treat autoimmunity inflammatory conditions,” said Deputy Editor of the Journal of Leukocyte Biology, John Wherry, PhD.
 
Now that scientists have an understanding about the anti-inflammatory capabilities of SIK-inhibitors, new drug candidates can be tested in animal models of chronic inflammation and autoimmune disease.
 

Sources: Crohn’s & Colitis Foundation of America, Arthritis Foundation, National Psoriasis Foundation, Federation of American Societies for Experimental Biology
 
About the Author
  • I am a scientific journalist and enthusiast, especially in the realm of biomedicine. I am passionate about conveying the truth in scientific phenomena and subsequently improving health and public awareness. Sometimes scientific research needs a translator to effectively communicate the scientific jargon present in significant findings. I plan to be that translating communicator, and I hope to decrease the spread of misrepresented scientific phenomena! Check out my science blog: ScienceKara.com.
You May Also Like
APR 08, 2021
Immunology
It's Not Just Cholesterol That Clogs Arteries
APR 08, 2021
It's Not Just Cholesterol That Clogs Arteries
Researchers have discovered a gene that is directly linked to the development of cardiovascular diseases, such as high b ...
APR 05, 2021
Cancer
Introducing DeepTCR, the deep-learning software for T-cell receptor sequencing data
APR 05, 2021
Introducing DeepTCR, the deep-learning software for T-cell receptor sequencing data
A team from the Bloomberg~Kimmel Institute for Cancer Immunotherapy at the Johns Hopkins Kimmel Cancer Center is introdu ...
MAY 04, 2021
Immunology
One Vaccine to Rule Them All
MAY 04, 2021
One Vaccine to Rule Them All
There are currently five variants of concern in the U.S., genetically distinct forms of the COVID-causing coronavirus th ...
MAY 05, 2021
Immunology
Novel 3D Bio-printed Leukemia Model Shows Potential for Treatment Testing Platform
MAY 05, 2021
Novel 3D Bio-printed Leukemia Model Shows Potential for Treatment Testing Platform
Three-dimensional (3D) printing has become a common technique over the past two decades. Now, the technique has been ado ...
MAY 19, 2021
Immunology
Intestinal Macrophages Promote Chronic Inflammation in Obesity
MAY 19, 2021
Intestinal Macrophages Promote Chronic Inflammation in Obesity
A research group from Switzerland hypothesized that immune cells in the gut (gastrointestinal tract) must trigger chroni ...
JUN 07, 2021
Health & Medicine
Higher Incidence of Breast Cancer in Polluted Urban Areas
JUN 07, 2021
Higher Incidence of Breast Cancer in Polluted Urban Areas
A Taiwanese study looked at the incidence of breast cancer in areas of Taiwan with varying levels of air pollutants. Air ...
Loading Comments...