MAY 03, 2016 02:08 PM PDT

Salt-Inducible Kinase Inhibitors Reduce Inflammation

WRITTEN BY: Kara Marker
In a new study published in the Journal of Leukocyte Biology, researchers from the University of Geneva discovered a new way to reduce inflammation associated with autoimmune diseases like Crohn’s disease, arthritis, and psoriasis. Salt-inducible kinase (SIK) activity is involved in multiple body processes, but this study shows that inhibiting these enzymes in specific cases could reduce the impact of chronic inflammation.
 

Crohn’s disease (CD) was first described in 1932 as an inflammatory bowel disease characterized by chronic inflammation of the gastrointestinal (GI) tract. CD usually occurs at the end of the ileum and the beginning of the large intestine, affecting the entire thickness of the GI tract wall. Patches of diseased intestine are also common, and patients diagnosed with CD often experience persistent diarrhea, rectal bleeding, abdominal pain, and constipation. Scientists do not know much more about the cause of CD other than connections to heredity, genetic mutations, and environmental factors.

Arthritis, on the other hand, is the leading cause of disability in America, characterized by a spectrum of joint diseases that appear in more than 100 different types and affect 50 million adults. Psoriasis is another autoimmune disease that causes patches of abnormal skin to appear, usually on the elbows, knees or scalp. Psoriasis is not contagious, and there are also several types: Different types: plaque psoriasis (most common), guttate, inverse, pustular, and erythrodermic (most severe).

In their study of two “structurally unrelated” inhibitors of SIK activity, researchers performed genetic interference (RNAi) tests to see what impact there would be on inflammation. They found that inhibiting salt-inducible kinase halts proinflammatory cytokine production and increases anti-inflammatory cytokine secretion by cultured human myeloid cells: monocytes, macrophages, and dendritic cells.

The researchers saw SIK-inhibitors resolving inflammation by preventing the interaction of SIK with TLR signaling. Usually this signaling limits the production of macrophages that produce interleukin-10, an anti-inflammatory molecule, and reduce levels of proinflammatory cytokine interleukin-12 and others.

"This work has the potential to add a new class of therapeutics for inflammatory disorders that could be used in combination with other distinct therapies in hard-to-treat autoimmunity inflammatory conditions,” said Deputy Editor of the Journal of Leukocyte Biology, John Wherry, PhD.
 
Now that scientists have an understanding about the anti-inflammatory capabilities of SIK-inhibitors, new drug candidates can be tested in animal models of chronic inflammation and autoimmune disease.
 

Sources: Crohn’s & Colitis Foundation of America, Arthritis Foundation, National Psoriasis Foundation, Federation of American Societies for Experimental Biology
 
About the Author
  • I am a scientific journalist and enthusiast, especially in the realm of biomedicine. I am passionate about conveying the truth in scientific phenomena and subsequently improving health and public awareness. Sometimes scientific research needs a translator to effectively communicate the scientific jargon present in significant findings. I plan to be that translating communicator, and I hope to decrease the spread of misrepresented scientific phenomena! Check out my science blog: ScienceKara.com.
You May Also Like
MAY 17, 2018
Immunology
MAY 17, 2018
Epigenetic Similarities Between Rheumatoid Arthritis and Huntington's Disease
A detailed investigation into the epigenome of rheumatoid arthritis (RA) patients revealed unexpected similarities between RA and Huntington’s diseas...
JUN 08, 2018
Cardiology
JUN 08, 2018
Interfering with Inflammatory Signals to Treat Arrhythmia
Part of the immune system has now been implicated in the development of atrial fibrillation (AF), the most common heart arrhythmia that leads to stroke, bl...
JUN 13, 2018
Immunology
JUN 13, 2018
Vitamin A Gives Immune System Power to Fight Tuberculosis
Multidrug-resistant tuberculosis bacteria are a serious health concern for the global population, but a new finding offers a new therapeutic solution that...
JUN 18, 2018
Immunology
JUN 18, 2018
Detecting and Diagnosing Rheumatoid Arthritis Before it Begins
Unique gene signatures and tiny changes in the immune system that occur in the earliest stages of rheumatoid arthritis, an autoimmune disease, could soon b...
JUN 22, 2018
Health & Medicine
JUN 22, 2018
A New Test for Peanut Allergy: Better, Faster, Cheaper.
Scientists from the Medical Research Council (MRC) in the UK have come up with a test to detect peanut allergies and it’s safer, quicker and more acc...
JUL 18, 2018
Immunology
JUL 18, 2018
Immunotherapy Increases Survival of Melanoma Brain Metastases Patients
Use of Checkpoint Blockade Immunotherapy increases survival rates in Melanoma Brain Metastases patients, with a 4-year survival rate increase from 11.1% to 28.1%...
Loading Comments...