MAY 03, 2016 2:08 PM PDT

Salt-Inducible Kinase Inhibitors Reduce Inflammation

WRITTEN BY: Kara Marker
In a new study published in the Journal of Leukocyte Biology, researchers from the University of Geneva discovered a new way to reduce inflammation associated with autoimmune diseases like Crohn’s disease, arthritis, and psoriasis. Salt-inducible kinase (SIK) activity is involved in multiple body processes, but this study shows that inhibiting these enzymes in specific cases could reduce the impact of chronic inflammation.
 

Crohn’s disease (CD) was first described in 1932 as an inflammatory bowel disease characterized by chronic inflammation of the gastrointestinal (GI) tract. CD usually occurs at the end of the ileum and the beginning of the large intestine, affecting the entire thickness of the GI tract wall. Patches of diseased intestine are also common, and patients diagnosed with CD often experience persistent diarrhea, rectal bleeding, abdominal pain, and constipation. Scientists do not know much more about the cause of CD other than connections to heredity, genetic mutations, and environmental factors.

Arthritis, on the other hand, is the leading cause of disability in America, characterized by a spectrum of joint diseases that appear in more than 100 different types and affect 50 million adults. Psoriasis is another autoimmune disease that causes patches of abnormal skin to appear, usually on the elbows, knees or scalp. Psoriasis is not contagious, and there are also several types: Different types: plaque psoriasis (most common), guttate, inverse, pustular, and erythrodermic (most severe).

In their study of two “structurally unrelated” inhibitors of SIK activity, researchers performed genetic interference (RNAi) tests to see what impact there would be on inflammation. They found that inhibiting salt-inducible kinase halts proinflammatory cytokine production and increases anti-inflammatory cytokine secretion by cultured human myeloid cells: monocytes, macrophages, and dendritic cells.

The researchers saw SIK-inhibitors resolving inflammation by preventing the interaction of SIK with TLR signaling. Usually this signaling limits the production of macrophages that produce interleukin-10, an anti-inflammatory molecule, and reduce levels of proinflammatory cytokine interleukin-12 and others.

"This work has the potential to add a new class of therapeutics for inflammatory disorders that could be used in combination with other distinct therapies in hard-to-treat autoimmunity inflammatory conditions,” said Deputy Editor of the Journal of Leukocyte Biology, John Wherry, PhD.
 
Now that scientists have an understanding about the anti-inflammatory capabilities of SIK-inhibitors, new drug candidates can be tested in animal models of chronic inflammation and autoimmune disease.
 

Sources: Crohn’s & Colitis Foundation of America, Arthritis Foundation, National Psoriasis Foundation, Federation of American Societies for Experimental Biology
 
About the Author
  • I am a scientific journalist and enthusiast, especially in the realm of biomedicine. I am passionate about conveying the truth in scientific phenomena and subsequently improving health and public awareness. Sometimes scientific research needs a translator to effectively communicate the scientific jargon present in significant findings. I plan to be that translating communicator, and I hope to decrease the spread of misrepresented scientific phenomena! Check out my science blog: ScienceKara.com.
You May Also Like
OCT 12, 2021
Drug Discovery & Development
Preventing future pandemics - Scientists developing broadly protective vaccines against coronaviruses
OCT 12, 2021
Preventing future pandemics - Scientists developing broadly protective vaccines against coronaviruses
Researchers at Japan’s Osaka University recently developed and tested a novel vaccine that may protect a ...
NOV 01, 2021
Cell & Molecular Biology
How SARS-CoV-2 Evades Antiviral Defenses
NOV 01, 2021
How SARS-CoV-2 Evades Antiviral Defenses
Researchers have learned a lot about the SARS-CoV-2 virus since the start of the COVID-19 pandemic. We know that he viru ...
NOV 21, 2021
Microbiology
Rare Genetic Variant Can Make People Susceptible to Bird Flu H7N9
NOV 21, 2021
Rare Genetic Variant Can Make People Susceptible to Bird Flu H7N9
Zoonosis is a serious health concern, as the COVID-19 pandemic has shown. Viruses that infect one species can acquire ge ...
DEC 11, 2021
Health & Medicine
The Vaccinated Can Still Get Long COVID
DEC 11, 2021
The Vaccinated Can Still Get Long COVID
Those who suffer from long COVID have persistent or new symptoms that weren't present during acute infection with SA ...
DEC 13, 2021
Cell & Molecular Biology
The Body Can Use Fat to Fuel the Fight Against Bacterial Infection
DEC 13, 2021
The Body Can Use Fat to Fuel the Fight Against Bacterial Infection
A new study reported in Nature Communications has shown how the body might use fat as fuel in the battle against a Salmo ...
DEC 30, 2021
Cell & Molecular Biology
Researchers Discover Immune Cell Subtype Linked to MS and Neuroinflammation
DEC 30, 2021
Researchers Discover Immune Cell Subtype Linked to MS and Neuroinflammation
We still don't know exactly what causes multiple sclerosis (MS), or many other disorders that involve inflammation in th ...
Loading Comments...