SEP 19, 2016 12:13 PM PDT

Plague Toxin Treats Common Autoimmune Disease

WRITTEN BY: Kara Marker
Yersinia pestis, the bacterial species responsible for numerous and deadly outbreaks of plague throughout human history, contains a toxin that might actually be beneficial to human health. 
Yersinia pestis bacteria | Credit: abc13.com
The same bacterial toxin that caused the 15th century “Black Death” epidemic of bubonic plague by invading host cells and disrupting valuable signaling responses to promote pathogenesis could be used to treat a common inherited autoimmune disease called Familial Mediterranean Fever (FMF). The autoinflammatory condition affects 1 in 200 to 1 in 1000 people in populations originating from the Mediterranean region, namely those with Armenian, Arab, Turkish, or Jewish ancestry.

Individuals with FMF have recurring episodes of painful inflammation in the abdomen, chest, or joints often accompanied by fever, rash, and headache, with initial episodes usually occurring during childhood or the teenage years. Episodes can be as short as 12 hours and as long as three days.

Lack of proper intervention in patients with FMF can lead to organ failure due to amyloidosis, the buildup of protein deposits in the body’s organs and tissues. FMF is passed down through generations in an autosomal dominant pattern, meaning it’s possible for a child to inherit the disease from just one affected parent.

The symptoms of FMF stem from mutations in a gene called MEFV, which is responsible for making a protein called pyrin, found in leukocytes. Pyrin is a regulator of inflammation, and when MEFV mutations inhibit ample production of pyrin, the inflammatory process can grow largely out of control.

Lead author of the recent Cell Host & Microbe study James Bliska, PhD., said the findings “may explain the natural selection process behind a chronic condition that affects a high prevalence of people originating around the Mediterranean Sea.” Bliska is a Professor in the Department of Molecular Genetics & Microbiology at Stony Brook University School of Medicine.

Bliska and his team researched the Y. pestis toxin, also found in bacterial species Y. pseudotuberculosis, because of its ability to recruit human kinases PRK1 and PRK2 to phosphorylate pyrin and subsequently restrict its inflammasome from causing an over-the-top autoimmune response from FMF-related MEFV mutations. 

So-called Yersinia outer proteins (Yops) promote pathogenesis by disrupting host signaling responses that control the immune response to bacterial infections. Miraculously, the same disruption that caused multiple epidemics and taking hundreds of thousands of lives could also be able to treat a common autoimmune disease with no known cure. 

Bliska and his team will continue to unravel the relationship between Yops and the control of FMF, encouraged by the increasing potential for drug developers to create new therapies that mimic this method of immune inhibition. 
 


Sources: Stony Brook University, Blood Journal, Genetics Home Reference
About the Author
  • I am a scientific journalist and enthusiast, especially in the realm of biomedicine. I am passionate about conveying the truth in scientific phenomena and subsequently improving health and public awareness. Sometimes scientific research needs a translator to effectively communicate the scientific jargon present in significant findings. I plan to be that translating communicator, and I hope to decrease the spread of misrepresented scientific phenomena! Check out my science blog: ScienceKara.com.
You May Also Like
AUG 06, 2020
Immunology
Resetting the Body's Danger Sensor
AUG 06, 2020
Resetting the Body's Danger Sensor
The human body has a sophisticated danger-sensing mechanism that alerts the immune system when something is not right. T ...
AUG 17, 2020
Immunology
Nervous Protein Neuromedin B May Prevent Immune Reactivity
AUG 17, 2020
Nervous Protein Neuromedin B May Prevent Immune Reactivity
A protein produced by the nervous system seems to play a role in regulating the immune system. For people with inflammat ...
AUG 18, 2020
Immunology
How Dolphins Could Help Us Live Longer
AUG 18, 2020
How Dolphins Could Help Us Live Longer
Dolphins are helping scientists answer the age-old question: can we stop the clock when it comes to aging? A recent stud ...
AUG 25, 2020
Immunology
Targeting Checkpoint Molecule Could Mean Checkmate for Cancer
AUG 25, 2020
Targeting Checkpoint Molecule Could Mean Checkmate for Cancer
In a new study published in Cell, researchers have identified a metabolic enzyme that could have powerful tumor-killing ...
SEP 21, 2020
Cell & Molecular Biology
The Hormones We Have at Birth Are Linked to Disease Throughout Life
SEP 21, 2020
The Hormones We Have at Birth Are Linked to Disease Throughout Life
New work may help explain why some autoimmune or immune-related diseases are more common in women, who are more likely t ...
NOV 12, 2020
Health & Medicine
Measles Cases and Deaths Surge Worldwide
NOV 12, 2020
Measles Cases and Deaths Surge Worldwide
Today, the World Health Organization (WHO) and the U.S. Centers for Disease Control and Prevention (CDC) released a stat ...
Loading Comments...