OCT 13, 2016 1:32 PM PDT

Limiting Immune Damage from Type 1 Diabetes

WRITTEN BY: Kara Marker
Over seven percent of individuals in the UK with type 1 diabetes are children, and the autoimmune diseases grows more common every year. Using a recombinant version of a chemical naturally produced already in the body, researchers from Cambridge are on the brink of a new treatment for type 1 diabetes that could reduce or even completely eliminate the need for regular insulin injections.
Image credit: Children's Hospital Los Angeles
When the body’s immune cells mistaken the insulin-producing cells of the pancreas, called beta cells, blood glucose levels begin to rise. This what defines type 1 diabetes, and this is what requires individuals with this disease to administer regular insulin shots to regulate blood glucose levels.

A study from the University of Cambridge JDRF/Wellcome Trust Diabetes Inflammation Laboratory at the Cambridge Institute of Medical Research led to the proposition of a new drug to regulate the type 1 diabetes autoimmune response: aldesleukin, a recombinant version of interleukin-2 (IL), a cytokine that wears many hats in the immune system. Aldesleukin is currently approved by the Food and Drug Administration (FDA) to treat melanoma and renal cell carcinoma in high doses.

“The current treatment [for type 1 diabetes] - multiple daily injections of insulin - are at best inconvenient, at worst painful, particularly for children," says Dr Frank Waldron-Lynch, who led the study. "Our goal is to develop a treatment that could see the end to the need for these life-long, daily injections by curtailing the early damage caused by the patient's own immune system.”

Waldron-Lynch and his team conducted their study to measure the ability of aldesleukin to regulate the immune response, using lower doses than the drug is currently used for to treat cancer. In the case of type 1 diabetes, aldesleukin works by enhancing the activity of regulatory T cells, which can limit the immune responses in autoimmune reactions. 

The results from extensive immune monitoring in 40 patients showed that the doses increased the level of regulatory T cells by 10-20 percent, the minimum needed to prevent an immune attack on insulin-producing cells and the maximum level to leave the effector immune cell activity intact in order to keep the rest of the body protected from infection.

Additionally, the results suggest that the drug shouldn’t be administered on a daily basis, so regulatory T cells won’t lose any sensitivity to aldesleukin.

"Our work is at an early stage, but it uses a drug that occurs naturally within the body to restore the immune system to health in these patients,” Waldron-Lynch said. “Whereas previous approaches have focused on suppressing the immune system, we are looking to fine-tune it.” 

In the future, Waldron-Lynch and the team plan on focusing the new aldesleukin-based treatment on people newly-diagnosed with type 1 diabetes who are still able to produce some insulin from beta cells. The study was recently published in PLOS Medicine.
 


Sources: University of Cambridge, American Diabetes Association, National Cancer Institute, Cytokine
About the Author
  • I am a scientific journalist and enthusiast, especially in the realm of biomedicine. I am passionate about conveying the truth in scientific phenomena and subsequently improving health and public awareness. Sometimes scientific research needs a translator to effectively communicate the scientific jargon present in significant findings. I plan to be that translating communicator, and I hope to decrease the spread of misrepresented scientific phenomena! Check out my science blog: ScienceKara.com.
You May Also Like
FEB 10, 2021
Drug Discovery & Development
Genetics Affect Response to Cancer Immunotherapy
FEB 10, 2021
Genetics Affect Response to Cancer Immunotherapy
Researchers have found that genetic factors may dictate as much as 20% of the efficacy of checkpoint inhibitors, a kind ...
MAR 18, 2021
Immunology
"Brainwashed" Immune Cells Help Breast Tumors Thrive
MAR 18, 2021
"Brainwashed" Immune Cells Help Breast Tumors Thrive
Immunologists have discovered a mechanism through which immune cells get recruited into breast cancer tumors, and instea ...
MAR 18, 2021
Immunology
COVID Cytokine Storm Chasers Look Inside the Lungs
MAR 18, 2021
COVID Cytokine Storm Chasers Look Inside the Lungs
Immunologists have revealed one of the underlying mechanisms behind COVID’s life-threatening cytokine storms. By s ...
MAR 22, 2021
Cell & Molecular Biology
Improving Cancer Immunotherapy While Reducing Autoimmune Side Effects
MAR 22, 2021
Improving Cancer Immunotherapy While Reducing Autoimmune Side Effects
Immunotherapy aims to make a patient's immune cells better at fighting cancer. The immune system has to be used carefull ...
APR 28, 2021
Cell & Molecular Biology
Learning More About the Sugars That Mediate Immune Interactions
APR 28, 2021
Learning More About the Sugars That Mediate Immune Interactions
Sugar is something sweet to add to your food, but just like fat, different types of sugars play important roles in biolo ...
MAY 05, 2021
Immunology
Novel 3D Bio-printed Leukemia Model Shows Potential for Treatment Testing Platform
MAY 05, 2021
Novel 3D Bio-printed Leukemia Model Shows Potential for Treatment Testing Platform
Three-dimensional (3D) printing has become a common technique over the past two decades. Now, the technique has been ado ...
Loading Comments...