OCT 13, 2016 01:32 PM PDT

Limiting Immune Damage from Type 1 Diabetes

WRITTEN BY: Kara Marker
Over seven percent of individuals in the UK with type 1 diabetes are children, and the autoimmune diseases grows more common every year. Using a recombinant version of a chemical naturally produced already in the body, researchers from Cambridge are on the brink of a new treatment for type 1 diabetes that could reduce or even completely eliminate the need for regular insulin injections.
Image credit: Children's Hospital Los Angeles
When the body’s immune cells mistaken the insulin-producing cells of the pancreas, called beta cells, blood glucose levels begin to rise. This what defines type 1 diabetes, and this is what requires individuals with this disease to administer regular insulin shots to regulate blood glucose levels.

A study from the University of Cambridge JDRF/Wellcome Trust Diabetes Inflammation Laboratory at the Cambridge Institute of Medical Research led to the proposition of a new drug to regulate the type 1 diabetes autoimmune response: aldesleukin, a recombinant version of interleukin-2 (IL), a cytokine that wears many hats in the immune system. Aldesleukin is currently approved by the Food and Drug Administration (FDA) to treat melanoma and renal cell carcinoma in high doses.

“The current treatment [for type 1 diabetes] - multiple daily injections of insulin - are at best inconvenient, at worst painful, particularly for children," says Dr Frank Waldron-Lynch, who led the study. "Our goal is to develop a treatment that could see the end to the need for these life-long, daily injections by curtailing the early damage caused by the patient's own immune system.”

Waldron-Lynch and his team conducted their study to measure the ability of aldesleukin to regulate the immune response, using lower doses than the drug is currently used for to treat cancer. In the case of type 1 diabetes, aldesleukin works by enhancing the activity of regulatory T cells, which can limit the immune responses in autoimmune reactions. 

The results from extensive immune monitoring in 40 patients showed that the doses increased the level of regulatory T cells by 10-20 percent, the minimum needed to prevent an immune attack on insulin-producing cells and the maximum level to leave the effector immune cell activity intact in order to keep the rest of the body protected from infection.

Additionally, the results suggest that the drug shouldn’t be administered on a daily basis, so regulatory T cells won’t lose any sensitivity to aldesleukin.

"Our work is at an early stage, but it uses a drug that occurs naturally within the body to restore the immune system to health in these patients,” Waldron-Lynch said. “Whereas previous approaches have focused on suppressing the immune system, we are looking to fine-tune it.” 

In the future, Waldron-Lynch and the team plan on focusing the new aldesleukin-based treatment on people newly-diagnosed with type 1 diabetes who are still able to produce some insulin from beta cells. The study was recently published in PLOS Medicine.
 


Sources: University of Cambridge, American Diabetes Association, National Cancer Institute, Cytokine
About the Author
  • I am a scientific journalist and enthusiast, especially in the realm of biomedicine. I am passionate about conveying the truth in scientific phenomena and subsequently improving health and public awareness. Sometimes scientific research needs a translator to effectively communicate the scientific jargon present in significant findings. I plan to be that translating communicator, and I hope to decrease the spread of misrepresented scientific phenomena! Check out my science blog: ScienceKara.com.
You May Also Like
MAY 17, 2018
Immunology
MAY 17, 2018
Epigenetic Similarities Between Rheumatoid Arthritis and Huntington's Disease
A detailed investigation into the epigenome of rheumatoid arthritis (RA) patients revealed unexpected similarities between RA and Huntington’s diseas...
JUN 06, 2018
Immunology
JUN 06, 2018
Why are women more prone to autoimmunity than men?
For a long time scientists have been trying to understand why females are more likely than males to develop autoimmune diseases. From the University of Got...
JUN 27, 2018
Immunology
JUN 27, 2018
Immune Cells Responsible for Chemo-induced Diarrhea
While studying specific immune cells in the context of chronic itching in the skin, two Washington University School of Medicine scientists discovered that...
JUN 28, 2018
Immunology
JUN 28, 2018
Synthetic T Cells the Next Big Thing in Immunotherapy
The highly complex structure and function of human T cells made the creation of synthetic versions of the immune cells difficult, but scientists from Unive...
JUL 30, 2018
Immunology
JUL 30, 2018
Traumatic Childhood to Addiction, an Immune System Problem
Childhood adversity alters the immune system which contributes to increased risk of addiction as an adult....
AUG 28, 2018
Drug Discovery
AUG 28, 2018
Combination Therapy for Advanced Melonoma
According to a research study led by UCLA, a bacteria-like agent used in combination with an immunotherapeutic drug may help patients survive longer with a...
Loading Comments...