MAR 19, 2017 7:49 PM PDT

Immune Cell Transforms in the Blood Vessels of Obese People

WRITTEN BY: Kara Marker

There is an new connection between obesity and hypertension, between the cardiovascular system and the immune response: immune cells called eosinophils. Recent discoveries revealed that these cells help regulate blood vessel function but become mysteriously sparse in obese individuals.

Eosinophils, which Dr. Sheena Cruickshank said are ““traditionally overlooked,” are white blood cells specifically designed to fight parasites, and they are also linked to some allergies, autoimmune diseases, and cancer subtypes. From the University of Manchester, Cruickshank is the lead researcher of a new Scientific Reports study on a new role for eosinophils.

According to Cruickshank’s findings, fighting parasites is simply an eosinophil’s day job; by night the cells are plentiful in the fatty layer of tissue surrounding blood vessels, a space called the perivascular adipose tissue (PVAT). The PVAT regulates blood vessel function by reducing artery contraction.

"This type of immune cell is present in many parts of the body and was once thought to just act in parasitic infections and allergies, but it's fast becoming clear that they have a significant effect on lots of aspects of health and immunity,” Cruickshank said.

While examining obese mice, researchers found that eosinophil levels were significantly reduced in their PVAT,  causing regulatory dysfunction and ultimately leading to obesity-related conditions like type 2 diabetes and hypertension.

Apparently the connection between drooping eosinophil levels and complications from obesity is due to these immune cells releasing of nitric oxide and adiponectin, a collagen-like protein involved in glucose and lipid metabolism in insulin-sensitive tissues. These secretions are important for healthy blood vessel function, explaining, at least in part, the connection between obesity and its complications.

The new discovery offers a new solution for drugs to target obesity, hypertension, and type 2 diabetes. Replenishing the PVAT with eosinophils could potentially relieve some of the effects caused by excessive weight gain.

Sources: University of Manchester, American Academy of Allergy, Asthma, and Immunology, Diabetes Care

About the Author
Master's (MA/MS/Other)
I am a scientific journalist and enthusiast, especially in the realm of biomedicine. I am passionate about conveying the truth in scientific phenomena and subsequently improving health and public awareness. Sometimes scientific research needs a translator to effectively communicate the scientific jargon present in significant findings. I plan to be that translating communicator, and I hope to decrease the spread of misrepresented scientific phenomena! Check out my science blog: ScienceKara.com.
You May Also Like
NOV 18, 2022
Cell & Molecular Biology
Mitochondria Can Signal to the Immune & Nervous Systems
Mitochondria Can Signal to the Immune & Nervous Systems
Mitochondria are little organelles that have long been known as the powerhouses of the cell. But in recent years, scient ...
DEC 23, 2022
Drug Discovery & Development
Onchilles Pharma's Newest Drug
Onchilles Pharma's Newest Drug
Onchilles Pharma is a small pharmaceutical company based in San Diego, USA. They work in oncology pharmacy, specifically ...
JAN 03, 2023
Immunology
An Antibody 'Decoy' Could Pave the Way for Better Immunotherapy
An Antibody 'Decoy' Could Pave the Way for Better Immunotherapy
Immunotherapy called CAR T cell therapy is a treatment that aims to train immune cells to get better at fighting disease ...
JAN 09, 2023
Microbiology
Looking for custom media? We are here to help.
Looking for custom media? We are here to help.
Are you looking for custom media manufactured in a FDA compliant facility? Hardy Diagnostics is an employee owned compan ...
JAN 19, 2023
Drug Discovery & Development
Introducing TruCytes™: The Ready-to-Use Immunophenotyping Control for Cell Therapy, Flow Cytometry and Beyond
Introducing TruCytes™: The Ready-to-Use Immunophenotyping Control for Cell Therapy, Flow Cytometry and Beyond
Are you a cell biologist, immunologist, or flow cytometrist? If so, you know how challenging it is to find quality contr ...
JAN 06, 2023
Clinical & Molecular DX
Discovery of Compound that Inhibits COVID and Colds
Discovery of Compound that Inhibits COVID and Colds
Researchers at the University of British Colombia’s Life Sciences Institute have identified a compound that can po ...
Loading Comments...