APR 15, 2016 7:56 PM PDT

Intestinal worms to cure IBD?

WRITTEN BY: Kerry Evans
Researchers at NYU Langone Medical Center found that helminth infection in the gut triggers immune responses that alter the gut microbiome, mitigating inflammatory bowel disease (IBD).

These results lend further support to the hygiene hypothesis. This hypothesis states that the absence of parasites - due to our exceptionally hygienic lifestyle - leaves the immune system highly responsive to changes in the gut. Supporters of the hygiene hypothesis think that a lack of exposure to antigens (microorganisms, parasites, etc.) early in life prevents the immune system from developing properly. This, in turn, affects how well the body establishes immune tolerance - making people susceptible to autoimmune disease.
 
Helminth infection may prevent IBD.

In fact, there is indeed a correlation between the low incidence of parasites in the developed world and high rates of inflammatory bowel diseases like ulcerative colitis and Crohn’s disease. According to study author P’ng Loke, “our findings are among the first to link parasites and bacteria to the origin of IBD, supporting the hygiene hypothesis”.

In their study, published in Science, the NYU researchers infected mice with helminths (intestinal worms) and characterized changes in the gut microbiome. What they saw was striking - nearly a thousand-fold decrease in bacteria belonging to the genus Bacteroides, and these bacteria are associated with IBD. The helminth infection also increased the number of species from the class Clostridia. These bacteria are associated with anti-inflammatory effects.

So, how do intestinal worms prevent IBD? The researchers think that the immune response to the worms produces an environment that is favorable to Clostridia, allowing these cells to grow. At the same time, this environment may be inhospitable to Bacteroides.

The study also reports that people living in rural Malaysia have relatively high rates of worm infection, low rates of IBD, and more Clostridia than Bacteroides in their guts. When these people were treated for the worm infections, they developed more Bacteroides than Clostridia in their microbiomes.

These findings could be the basis for future IBD treatments that involve treating patients with immune-stimulating drugs, mimicking the response to a worm infection.

Sources: Science, Science Daily, Wikipedia
About the Author
  • Kerry received a doctorate in microbiology from the University of Arkansas for Medical Sciences.
You May Also Like
DEC 01, 2019
Microbiology
DEC 01, 2019
Some Antacids Appear to Increase the Risk of Gastroenteritis
Proton pump inhibitors (PPIs) are drugs for heartburn relief; they can reduce stomach acid levels....
DEC 15, 2019
Cell & Molecular Biology
DEC 15, 2019
Using a Bacterial Syringe to Deliver Proteins to Cells
Researchers want to use a pathogen's strategy for therapeutic purposes....
JAN 01, 2020
Microbiology
JAN 01, 2020
Manuka Honey Can Help Fight Infections After Surgery
Honey has been used in homeopathic medicine as a wound healer, and now researchers have developed a special application for it....
JAN 28, 2020
Technology
JAN 28, 2020
Portable device analyzes microbes in the environment
Aquatic microbes often serve as challenge to study, after all, they are too tiny to detect. But, what if there was a device that can swiftly analyze aquati...
FEB 03, 2020
Drug Discovery & Development
FEB 03, 2020
HIV Viral Structures Improve Therapeutics
Researchers have recently discovered how a powerful class of HIV drugs bind to a key piece of HIV machinery. Their findings, for the first time, shows how ...
FEB 11, 2020
Clinical & Molecular DX
FEB 11, 2020
Portable device turns smartphones into diagnostic labs
Your smartphone lets you connect with friends, stores your memories, sends work emails and pays for your groceries. Soon, it could even help diagnose if yo...
Loading Comments...