JUN 22, 2016 12:45 PM PDT

Don't scratch that itch!

WRITTEN BY: Kerry Evans
Summer means mosquitoes. Mosquitoes mean itchy mosquito bites.

Those itchy bites aren’t just a nuisance, they actually boost the spread of mosquito-borne viruses.

Mosquitoes inject saliva into your skin when they bite (ew). The saliva attracts immune cells that surround the site of the bite. If you think these immune cells would help keep the injected virus from spreading, you’re be wrong. A recent study found that the virus actually ends up hitching a ride with these immune cells to different parts of the body.
 
Inflamed mosquito bites boost viral infection.

This study, published in the journal Immunity by researchers from the University of Leeds, tested whether or not the inflammation that accompanies a mosquito bite helps establish a viral infection.

The group injected Semliki Forest virus or Bunyamwera virus into the skin of mice - with or without an accompanying mosquito bite at the injection site.  

When no mosquito bite was present, the virus did not replicate well in the skin. They reasoned that the inflammatory response that occurs after a mosquito bite may have something to do with how well the virus replicates. They found that mosquito bites attracted a large number of cutaneous neutrophils to the bite site - however, virus infection alone did not induce this response.

The group also performed one particularly interesting experiment to show that neutrophil-dependent inflammation enhanced viral infection. They depleted the neutrophils in their mice and found that this reduced the abundance of viral RNAs at the injection site by roughly 5-fold.

The next step is to identify ways to reduce the inflammation associated with mosquito bites. According to study author Clive McKimmie, “we now want to look at whether medications such as anti-inflammatory creams can stop the virus establishing an infection if used quickly enough after the bite inflammation appears”.
 


Sources: Immunity, University of Leeds
 
About the Author
  • Kerry received a doctorate in microbiology from the University of Arkansas for Medical Sciences.
You May Also Like
JAN 20, 2020
Microbiology
JAN 20, 2020
Microbes Create a More Sustainable Building Material
Concrete is the second most widely consumed resource on the planet (after water), and it has a massive carbon footprint....
JAN 21, 2020
Microbiology
JAN 21, 2020
New Coronavirus is Spreading in China
In late December, health officials in China notified WHO that pneumonia with an unknown cause was sickening people....
FEB 08, 2020
Microbiology
FEB 08, 2020
Novel Coronavirus Has Now Infected At Least 34,500 People
In China, authorities are still struggling to contain the new coronavirus that emerged in the city of Wuhan and has since spread around the globe....
FEB 12, 2020
Drug Discovery & Development
FEB 12, 2020
Does Traditional Chinese Medicine Work Against Coronavirus?
Over 45,000 cases of Wuhan Coronavirus have been reported globally, alongside over 1,100 deaths. Although over 4,700 people are said to have recovered from...
MAR 25, 2020
Microbiology
MAR 25, 2020
The Patterns Formed by Biofilms
Bacterial cells grow in colonies called biofilms, which take on new characteristics, and can form intricate patterns....
MAR 30, 2020
Genetics & Genomics
MAR 30, 2020
Scientists Discover an Antibiotic Resistance Gene
The gene enables bacteria to resist the effects of an aminoglycoside antibiotic called plazomycin....
Loading Comments...