JUN 22, 2016 1:16 PM PDT

Statins for Heart Health: Only Effective Sometimes?

WRITTEN BY: Kara Marker
The European Society of Cardiology recommends treatment for people with ischemic heart disease (IHD) to achieve low-density lipoprotein cholesterol (LDL-C) levels below 70 mg/dL, but the American Heart Association has no recommendations on LDL-C levels. This discrepancy directed scientists to explore further the effect of LDL-C levels and the cholesterol-lowering statins on patients with IHD, the subject of a study recently published in JAMA Internal Medicine.
Credit: BBC
Statins lower cholesterol levels when diet and exercise can’t do the job, and they work by disrupting the initial production of cholesterol that occurs in the liver. The new study of over 30 thousand patients with pre-existing IHD attempted to answer why statins lower the risk for a major adverse cardiac event (MACE) for some patients and not for others.
 
LDL-C is often known as the “bad” kind of cholesterol, and it lives up to its notoriety by building up in the arteries at elevated levels, increasing the risk for atherosclerosis, a buildup of plaque in the blood vessels. LDL-C levels are most likely to be elevated in a person who maintains a diet high in saturated and trans fats.
 
Researchers looked at 31,619 with preexisting IHD and at least 80 percent “adherent” to statin treatment. Each patient in the study had been receiving statin treatment for at least one year.
 Credit: healthyprotocols.com
Approximately 30 percent of the patients presented with low levels of LDL-C, considered to be 70 mg/dL or lower, 50 percent with moderate levels (70.1 – 100 mg/dL), and 20 percent high levels (100.1 – 130 mg/dL). After an average 1.6 years of follow-up time, 9,035 patients either had a MACE or died. Researchers consider a MACE to be one of the following events:
  • heart attack
  • unstable angina
  • stroke
  • angioplasty
  • bypass
  • death
While the resarchers did not find low levels of LDL-C to be significantly associated with an elevated risk of a MACE as compared to patients with moderate LDL-C levels, they did find a significant reduction in risk for patients with moderate levels of LDL-C as compared to patients with high LDL-C levels.
 
The researchers from the study are hesitant to apply their results to a wide variety of IHD cases until further studies can be completed. "Our results do not provide support for a blanket principle that lower LDL-C is better for all patients in secondary prevention," they decided.
 
Regardless, most patients with stable IHD are recommended by doctors to receive long-term treatment with statins to reduce their risk of “recurring cardiovascular events.”
 

 
Sources: The JAMA Network Journals, MedlinePlus, NC Research Campus
 
 
About the Author
  • I am a scientific journalist and enthusiast, especially in the realm of biomedicine. I am passionate about conveying the truth in scientific phenomena and subsequently improving health and public awareness. Sometimes scientific research needs a translator to effectively communicate the scientific jargon present in significant findings. I plan to be that translating communicator, and I hope to decrease the spread of misrepresented scientific phenomena! Check out my science blog: ScienceKara.com.
You May Also Like
JUN 08, 2019
Cardiology
JUN 08, 2019
You Might Not Know You Have Anemia
Of all the blood disorders, anemia is the most common. According to The Heart Lung and Blood Institute, it affects over 3 million Americans. Some people wi...
JUN 23, 2019
Health & Medicine
JUN 23, 2019
Can Sauna Sessions Replace Exercise?
A moderate sauna session after a workout or spa treatment can be quite relaxing. A new study from Germany's Martin Luther University Halle-Wittenberg (...
JUL 29, 2019
Drug Discovery & Development
JUL 29, 2019
Medications Used for Atrial fibrillation May Increase Falls
Falls among older adults are a growing health concern that often lead to injury, hospitalization, and other severe complications. Older adults are even at...
SEP 06, 2019
Cardiology
SEP 06, 2019
Poor U.S. Counties Have More Heart Failure Deaths
In 2009, one in nine U.S. deaths included heart failure as contributing cause, according to the Centers for Disease Control (CDC). And about half of the pe...
SEP 10, 2019
Genetics & Genomics
SEP 10, 2019
Gene Mutations Link Flu Infections and Heart Trouble
Sometimes people develop life-threatening heart complications when they're infected with the flu....
JAN 04, 2020
Cardiology
JAN 04, 2020
New Protein Therapy Improves Heart Attack Survival Rates
Heart disease is the top killer in the Western world. This is partially because, if one manages to survive an initial heart attack, oftentimes the scar tis...
Loading Comments...