NOV 09, 2016 06:30 PM PST

Iron-Scavenging Molecule may be key to UTI Prevention

WRITTEN BY: Carmen Leitch
Urinary tract infections (UTIs), which are primarily caused by uropathogenic Escherichia coli (UPEC), are becoming more difficult to treat as antibiotic resistance rises. Around one in 40 women suffer from recurrent UTIs. Vaccines are not currently available for use in the United States. A new report by University of Michigan Medical School researchers in the Proceedings of the National Academy of Sciences has identified a new strategy for UTI prevention using a molecule required by the pathogenic E coli.
 


The pathogenic bacteria that cause UTIs use an iron-scavenging molecule, or siderophore, to take advantage of the iron supply used by host cells. That aids the bacteria in taking hold and replicating inside the bladder, and promotes virulence. The siderophores are unique to the immune system of the host and can evade it. That has made them attractive targets for vaccines. In a new development in the use of siderophores in UTI prevention, scientists tried applying two different ones to the inside of the noses of mice a few times over a period of two weeks.
 
The individual application of the siderophores only provided a modest amount of protection against UTIs – in the experiments, the mice modeled UTIs after receiving a direct application of UPEC to their bladders. The researchers tried applying the siderophores at the same time, also utilizing a carrier protein. Using that strategy in the mice, an immune response was observed that provided some protection against UTIs.
 
"We saw efficacy more in the kidney than in the bladder, suggesting that this approach may be most useful in preventing advanced UTIs," said first author and research fellow Laura Mike. "Our next challenge is creating a combination vaccine that also employs proteins that UPEC bacteria use to bind their iron-laden siderophores, and test other adjuvants to increase the response."
 
This work is the best use of siderophores in the prevention of UTIs. Previous research has attempted to use a vaccine made up of proteins from the UPEC. Using the vaccine with the siderophore could be a way to totally prevent UTIs. Recent research, outlined in the video below, has shown that cranberry juice is not an effective way to prevent UTIs, making the work more urgent.
 

Since other pathogenic bacterium also produce siderophores, this approach might be useful in the fight against other bugs. "Using proteins that are found on the surface of bacterial cells as the basis for vaccination may lack efficacy because of the variability of the exact protein structure," said Harry Mobley, Ph.D., senior author of the new paper and chair of the Department of Microbiology and Immunology at UM. "But siderophores are the same across most gram negative enteric bacteria that cause some of the worst infections. This is a step along the journey, but it's an encouraging one."
 
 
Source: AAAS/Eurekalert! via University of Michigan Health System, Scientific Reports, PNAS
 
About the Author
  • Experienced research scientist and technical expert with authorships on 28 peer-reviewed publications, traveler to over 60 countries, published photographer and internationally-exhibited painter, volunteer trained in disaster-response, CPR and DV counseling.
You May Also Like
JUL 03, 2018
Immunology
JUL 03, 2018
Here's a Virus that Boosts the Immune System
There’s a new therapeutic approach to boosting the weakened immune system that develops naturally with age, but it’s anything but conventional....
JUL 17, 2018
Microbiology
JUL 17, 2018
Understanding how Microbes Will Accelerate Climate Change
As permafrost starts to thaw out, it's exposing untold numbers of new bacteria, which can spew out methane....
JUL 23, 2018
Genetics & Genomics
JUL 23, 2018
Developing Self-fertilizing Plants
Plants of the future may not need to be fertilized; they might create their own nutrients. That could be a huge relief for the planet....
JUL 27, 2018
Microbiology
JUL 27, 2018
Making Accurate Assessments of the Environmental Impact of Pollution
Without the right experimental design, behavioral testing can easily produce the wrong results....
AUG 25, 2018
Videos
AUG 25, 2018
Bacterial Memories
Some bacteria have a way of remembering things like antibiotics, which helps them escape future encounters....
OCT 02, 2018
Drug Discovery
OCT 02, 2018
Mycobacterial Lung Disease, FDA Approves New Drug
New drug seeking to treat antibiotic-resistant lung disease has just been approved by the U.S. Food and Drug Administration. The drug is called ‘Arik...
Loading Comments...