MAR 06, 2017 07:35 PM PST

Progress in the Fight Against Killer Superbugs

WRITTEN BY: Carmen Leitch

Last September, the United Nations gathered to recognize the serious threat that antibiotic resistance poses to the public. It is estimated that antibiotic resistance is responsible for the deaths of over 700,000 people worldwide annually. Only a few days ago, the World Health Organization released a list of the microbial pathogens that pose the biggest threat to human health. Needless to say, any progress in this fight is a benefit to people. Researchers have some good news in the face of all the warnings; it appears that a drug combination is effective against two of the three pathogenic bacteria identified by WHO as well as another dangerous pathogen, all of which are gram negative bacteria. These findings have been reported in Nature Microbiology. You can check outran interview with a principle scientists about the work in the following video.

Gram-negative bacteria have a impervious outer shell that serves as a shield against many commonly used, and usually effective bacteria. That makes for an especially tough bug, causing many deaths, especially in hospital settings.

"These pathogens are really hard nuts to crack, but we found a molecule that shreds that shell and allows antibiotics to enter and be effective," explained the senior author of the report, Eric Brown, a Professor of Biochemistry and Biomedical Science at McMaster's Michael G. DeGroote School of Medicine and a scientist of the Michael G. DeGroote Institute for infectious Disease Research. You can check out an interview with Brown in the video above. "We looked for compounds that would mess with these bacteria, and I think we're nailing it."

The researchers determined that an antiprotozoal drug called pentamidine breaks into the surface of even the most resistant Gram-negative bacteria. When this antifungal drug was used in combination with antibiotics, it was effective against multi drug resistant antibiotics. "These pathogens are really hard nuts to crack, but we found a molecule that shreds that shell and allows antibiotics to enter and be effective," said Brown.

When pentamidine was used with antibiotics it could combat enterobacteriaceae and Acinetobacter baumannii, two drugs on the list released by WHO. This combination of drugs was also effective against another dangerous pathogen, Pseudomonas aeruginosa. These results were modeled in rodents and in the lab, and now testing will have to investigate the side effects and safety for use in humans. Brown's lab continues to search for more therapies. "One of the things we want to pursue further is why this is working so well," he concluded. 

You can check out report about the United Nations' meeting on antibiotic resistance in the following video.

Sources: AAAS/Eurekalert! via McMaster University, Nature Microbiology

About the Author
  • Experienced research scientist and technical expert with authorships on 28 peer-reviewed publications, traveler to over 60 countries, published photographer and internationally-exhibited painter, volunteer trained in disaster-response, CPR and DV counseling.
You May Also Like
SEP 22, 2018
Videos
SEP 22, 2018
Did a Vampire Facial Expose Patients to Bloodborne Disease?
It seems there is no shortage of unusual beauty rituals; vampire facials may fall into that category....
OCT 08, 2018
Genetics & Genomics
OCT 08, 2018
Neanderthal DNA Helps us Fight Viruses
The last Neanderthals died around 40,000 years ago, but not before breeding with other humans that were starting to move around the globe....
OCT 16, 2018
Videos
OCT 16, 2018
Can the Bacteria That we Carry Give us Special Powers?
The bacteria that we carry in and on our bodies can affect our health and well-being in many ways....
OCT 25, 2018
Microbiology
OCT 25, 2018
Single-cell Genomics Expands the Fungal Tree of Life
Our environment contains millions of other organisms, including fungal species that live in every conceivable place....
NOV 03, 2018
Microbiology
NOV 03, 2018
Potential new Tuberculosis Treatment Found in Dirt
The pathogen that causes TB has been able to evolve, and often, the typical therapeutic for the illness does not work....
NOV 06, 2018
Videos
NOV 06, 2018
Towards a Universal Flu Vaccine
Researchers have to design a new flu vaccine every year. But there are efforts to create a vaccine that works against all strains....
Loading Comments...