JUL 20, 2017 07:36 PM PDT

Municipal Wastewater Could be a Source for new Antimicrobials

WRITTEN BY: Carmen Leitch

As antibiotic-resistance among pathogens becomes an ever-bigger problem, the pressure is on to find new antibiotics. That has sent researchers looking in some unusual places for new compounds, like in soil or wastewater. New research from scientists at Stellenbosch University (SU) has found that bacteria naturally living in community wastewater synthesize compounds that have antimicrobial properties. The work is described in the following video.

 

 

"Certain bacteria in municipal wastewater produce antimicrobial compounds or biosurfactants that can help prevent the growth of antibiotic-resistant microorganisms which cause serious infections in humans," explained postdoctoral researcher Dr. Thando Ndlovu, of the Department of Microbiology at SU. He has published findings on this topic in Environmental Science and Pollution Research.

 

For this study, Ndlovu gathered samples from wastewater, then assayed them with various tests. He was able to find and isolate two bacterial strains that produce biosurfactants that can fight pathogenic, antibiotic-resistant microbes. Bacteria use the surfactants for various purposes, including helping to import energy or changing cell wall composition. Humans have taken notice, and utilized surfactants for myriad purposes in the cosmetic, agriculture and medical industries, among others.

 

"The biosurfactants produced by the two bacteria in my study prevented the growth of major disease-causing bacteria such as methicillin-resistant Staphylococcus aureus and gentamicin-resistant E. coli which can lead to life-threatening infections in humans," noted Ndlovu.

 

"This finding is promising given worldwide reports on the number of deaths caused by antimicrobial resistant microorganisms that are becoming increasingly difficult to treat with current drugs,” he continued. “The discovery of novel antimicrobial compounds is a priority and biosurfactant compounds could be used to develop new antibiotics for treatment of various infections caused by antibiotic resistant bacteria and eventually replace ineffective antibiotics in future."

This is South African microbiologist, Dr Thando Ndlovu in his laboratory in the Department Microbiology, Stellenbosch University. / Credit: Stefan Els

Ndlovu suggested that municipal wastewater is rich with opportunities to discover many different kinds of bacteria that synthesize surfactants. Many of these bacterial surfactants could have beneficial applications.

 

"While numerous studies have reported on the isolation of biosurfactant-producing bacteria from contaminated soil and terrestrial environments, the current study indicated that municipal wastewater could be exploited for the isolation of diverse biosurfactant-producing bacterial strains,” said Ndlovu.

 

“Biosurfactant-producing bacteria thrive in polluted environments such as contaminated soil or water. These bacteria also have the ability to outcompete other bacteria in the same environment because the biosurfactant compounds help them to absorb nutrients and to protect them from toxic materials."

 

These biosurfactant compounds might also help reduce the widespread use of unnatural antimicrobial molecules in cleaning products and microbial barriers. Future research aims to study how these biosurfactants can be used to their full advantage.


 

Sources: AAAS/Eurekalert! Via Stellenbosch University, Current Science, Environmental Science and Pollution Research

 
About the Author
  • Experienced research scientist and technical expert with authorships on 28 peer-reviewed publications, traveler to over 60 countries, published photographer and internationally-exhibited painter, volunteer trained in disaster-response, CPR and DV counseling.
You May Also Like
OCT 22, 2019
Microbiology
OCT 22, 2019
Is Climate Change to Blame for the Rise of Candida auris?
In recent years, the fungus Candida auris has emerged as a growing public health threat. The infection is usually serious and tough to treat effectively....
OCT 22, 2019
Genetics & Genomics
OCT 22, 2019
Studying Mice That Harbor the Bacteria That Cause Lyme Disease
Lyme disease is on the rise, and researchers are working to learn more about how it's transmitted....
OCT 22, 2019
Microbiology
OCT 22, 2019
The Microbiome is Affected by the Genome of Its Host
Many factors influence the composition of our microbiome, including our genes....
OCT 22, 2019
Microbiology
OCT 22, 2019
Salmonella Becomes More Deadly and Drug-Resistant in Central Africa
An international team of scientists has identified strains of extensively drug-resistant Salmonella typhimurium....
OCT 22, 2019
Microbiology
OCT 22, 2019
Raw and Cooked Foods Have Different Effects on the Microbiome
The gut microbes we carry are impacted by many factors, including our diet....
OCT 22, 2019
Drug Discovery & Development
OCT 22, 2019
Nanomesh Development Advances Drug Delivery's Fight Against Antibiotic-Resistance
As concern over medication-resistant bacteria grows, researchers at Flinders University have now fabricated nanomeshes as an effective drug delivery method...
Loading Comments...