JUN 04, 2015 4:41 PM PDT

Giggles and the Genes

WRITTEN BY: Ilene Schneider
Researchers, including a group at the Department of Psychology at the Technische Universitat Dresden in Germany, have wondered whether the serotonin transporter gene-linked polymorphic region (5-HTTLPR) is associated with higher vulnerability to psychiatric diseases when exposed to environmental challenges. Possibly explaining genotype-dependent differences in stress sensitivity, these researchers evaluated the association of 5-HTTLPR genotype and cortisol reactivity to acute psychosocial stress (http://www.researchgate.net/publication/230790613_The_serotonin_transporter_gene-linked_polymorphic_region_(5-HTTLPR)_and_cortisol_stress_reactivity_a_meta-analysis). Clearly, the variations on this gene were no laughing matter.
Giggling can be the result of genetic variations.
Now that same gene, which has been linked to both marital bliss and sadness, is thought to make some people more prone to spontaneous smiles and bursts of laughter. For a new study, researchers looked at two versions of 5-HTTLPR and determined that people with the short version were more likely to smile and laugh while looking at "Far Side" and New Yorker cartoons and humorous clips from the movie Strangers in Paradise (http://www.futurity.org/laughter-genes-935442/).

Published in the journal, Emotion, and reported on futurity.com, the study entailed videotaping the facial expressions of 336 participants and coding them for genuine signs of amusement, such as crow's feet around the eyes, after collecting their saliva samples to determine if they had the long or short version of the 5-HTTLPR gene. People with the short allele showed more authentic smiles and laughter than those with the long-allele. In an earlier study people with the short variant of 5-HTTLPR appeared to be more sensitive to their spouse's positive and negative emotions, causing researchers to suggest that DNA is related to marital satisfaction.

The new study "provides a more complete picture of the emotional life of people with the short allele," according to lead author Claudia Haase, assistant professor of human development and social policy at Northwestern University. Study senior author Robert Levenson, professor of psychology at the University of California, Berkeley, added, "This study provides a dollop of support for the idea that positive emotions are under the same tent as negative ones, when it comes to the short allele. It may be that across the whole palette of human emotions, these genes turn up the gain of the amplifier. It sheds new light on an important piece of the genetic puzzle."

Other researchers from UC Berkeley, and from UC San Francisco and University of Geneva are coauthors of the study.
About the Author
Ilene Schneider is the owner of Schneider the Writer, a firm that provides communications for health care, high technology and service enterprises. Her specialties include public relations, media relations, advertising, journalistic writing, editing, grant writing and corporate creativity consulting services. Prior to starting her own business in 1985, Ilene was editor of the Cleveland edition of TV Guide, associate editor of School Product News (Penton Publishing) and senior public relations representative at Beckman Instruments, Inc. She was profiled in a book, How to Open and Operate a Home-Based Writing Business and listed in Who's Who of American Women, Who's Who in Advertising and Who's Who in Media and Communications. She was the recipient of the Women in Communications, Inc. Clarion Award in advertising. A graduate of the University of Pennsylvania, Ilene and her family have lived in Irvine, California, since 1978.
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