JUL 17, 2015 3:42 PM PDT

Autistic Brains Differ Biologically

WRITTEN BY: Ilene Schneider
What causes autism? Is there something physical that accounts for behavioral differences?
Some brain cells overpower others in autistic brains, causing differences in behavior, according to some researchers.
Researchers have grown brainlike cell bundles in a lab to show the biological differences of autistic brains. They chemically reprogrammed human stem cells into "organoids," small bundles of functional brain cells that mimic the developing brain. The organoids built with cells from autistic patients seem to be different from those built with cells from the patients' non-autistic family members, the team reported in Cell, as related in Science News (https://www.sciencenews.org/blog/science-ticker/bundles-cells-hint-biological-differences-autistic-brains).

The scientists found that the brainlike structures developed from cells extracted from autistic children demonstrated increased activity in genes that control brain-cell growth and development. If there was too much activity in one of these genes, there was an overproduction of a certain type of brain cell that suppresses the activity of other brain cells.

According to the researchers, "At an early stage of development, the miniature organs grown from autistic patients' stem cells also showed faster cell division rates than those grown from the cells of non-autistic relatives. Though the study was small, using cells from only four autistic patients and eight family members, the results may indicate common factors underlying autism."

Why is the study so important? Autism is invisible and poorly understood. It affects personal and professional relationships. People who can get appropriate medication and therapy and who have a good support system can manage to function, but many people do not have these advantages (https://www.sciencenews.org/article/adults-autism-are-left-navigate-jarring-world).

"Autism spectrum disorder," which may affect 1 in 68 children, includes a group of neurological disorders widely ranging in severity. Among them are problems in communication and social interaction, challenges with regulating emotions and repetitive or obsessive behaviors and interests. About half of the children who have an autism spectrum disorder are "high functioning," meaning they have average or above-average intelligence.

While the United States spends more than $400 million every year on autism research, most of it is either for genetics research to determine causes and cures or for studies on early diagnosis and intervention in children. Rarely are there studies on treatments for adults.

Accepted approaches for treating children with autism range from brief interventions for addressing specific challenges like recognizing facial expressions to comprehensive behavioral training programs that involve parents, teachers and peers. No drugs have been approved to treat the basic symptoms of autism in children or adults, but some people who are diagnosed with autism are on medications for conditions that can occur alongside autism, including depression, anxiety and irritability.
About the Author
  • Ilene Schneider is the owner of Schneider the Writer, a firm that provides communications for health care, high technology and service enterprises. Her specialties include public relations, media relations, advertising, journalistic writing, editing, grant writing and corporate creativity consulting services. Prior to starting her own business in 1985, Ilene was editor of the Cleveland edition of TV Guide, associate editor of School Product News (Penton Publishing) and senior public relations representative at Beckman Instruments, Inc. She was profiled in a book, How to Open and Operate a Home-Based Writing Business and listed in Who's Who of American Women, Who's Who in Advertising and Who's Who in Media and Communications. She was the recipient of the Women in Communications, Inc. Clarion Award in advertising. A graduate of the University of Pennsylvania, Ilene and her family have lived in Irvine, California, since 1978.
You May Also Like
AUG 28, 2020
Genetics & Genomics
'Jumping' Genes Can Regulate Gene Expression in Human Neurons
AUG 28, 2020
'Jumping' Genes Can Regulate Gene Expression in Human Neurons
Even though genes that code for protein have been an intense focus of biomedical research for decades, the human genome ...
SEP 08, 2020
Neuroscience
Thyroid Inflammation Linked to Anxiety Disorder
SEP 08, 2020
Thyroid Inflammation Linked to Anxiety Disorder
Findings from a new study suggest that people with autoimmune inflammation in their thyroid may be more likely to develo ...
SEP 21, 2020
Neuroscience
Scientists Compare Structural and Functional Evolution with First Atlas of Cavefish Brains
SEP 21, 2020
Scientists Compare Structural and Functional Evolution with First Atlas of Cavefish Brains
Cavefish are fish that dwell in caves, unable to access the outside world. Often, they were separated from their closest ...
SEP 11, 2020
Immunology
Study Reveals Tumor Defense Mechanism... And How to Beat It
SEP 11, 2020
Study Reveals Tumor Defense Mechanism... And How to Beat It
  P53 is an infamous process gene at the core of the development of tumors.  When P53  functional, it pau ...
OCT 29, 2020
Clinical & Molecular DX
More Frequent Trips to the Pediatrician Linked to a Future Autism Diagnosis
OCT 29, 2020
More Frequent Trips to the Pediatrician Linked to a Future Autism Diagnosis
 
NOV 07, 2020
Cannabis Sciences
Does Cannabis Make Bipolar Disorder Better or Worse?
NOV 07, 2020
Does Cannabis Make Bipolar Disorder Better or Worse?
While anecdotal evidence and some case studies suggest cannabis may benefit those with bipolar disorder, studies have re ...
Loading Comments...