FEB 26, 2020 7:01 PM PST

Immunotherapy Could Be Used to Treat Traumatic Brain Injury

WRITTEN BY: Amanda Mikyska

Video:  Further explaination of microglia and their various functions. 

Traumatic Brain Injuries are physical injuries to the brain which cause inflammation and are known to cause neurodegenerative diseases like Alzheimer’s, Dementia, and Chronic Traumatic Encephalopathy (CTE), which has been in sports headlines regarding concussions.  Researchers at Trinity College in Dublin and the University of Maryland School of Medicine are working on a possible immunotherapy to reduce inflammation after a TBI and reduce risk of neurodegenerative diseases.  

When a person experiences a TBI, for example a concussion, microglia cells become inflamed and effectively form a protective cushion around the brain.  Microglia are the brain’s immune cells, but long periods of inflammation, or many cycles of inflammation, cause neurological and cognitive damage.  

The researchers have now shown that inhibiting a gene in the microglia, necessary for their survival, will decrease inflammation and reduce risk of developing a neurodegenerative disease.  The researchers controlled a TBI in mice, then one month after the injury, they inhibited the CSF1R receptor in microglia cells. One week after inhibition, the receptor was controlled to resume normal activity.  The researchers found that turning off the critical receptor killed 95% of microglia cells, which dramatically decreased inflammation. Furthermore, when the receptors were allowed to resume activity, they were “reset” to normal activity, not a highly inflamed state.  

Though this is an early study in mice, researchers from a variety of backgrounds are interested in testing the concept with more specific parameters. 

 

Sources: Henry, et. al., PubMed, NeuroscienceNews

About the Author
  • Amanda graduated from the University of Massachusetts Boston with a degree in Biology. After working in research on creating biochemicals from genetically engineered yeast, she started freelance science writing while traveling the world. Now, Amanda is a Lab Manager and Research Assistant at the the University of Central Florida, studying the molecular phylogeny of parasitic wasps. She writes about the latest research in Neuroscience, Genetics & Genomics, and Immunology. Interested in working on solutions for food/water security, sustainable fuel, and sustainable farming. Amanda is an avid skier, podcast listener, and has run two triathlons.
You May Also Like
MAY 20, 2021
Cannabis Sciences
Cannabis Improves Symptoms in Over Half of Patients with Parkinson's Disease
MAY 20, 2021
Cannabis Improves Symptoms in Over Half of Patients with Parkinson's Disease
Researchers from the University Medical Center Hamburg-Eppendorf in Germany have found that cannabis products may produc ...
JUL 15, 2021
Infographics
Ketamine's Effects on Pain and Mental Health
JUL 15, 2021
Ketamine's Effects on Pain and Mental Health
Ketamine is receiving increasing amount of attention both for its effects in mental health- particularly in depression- ...
JUL 05, 2021
Drug Discovery & Development
ADHD Drug Reduces Daydreaming, Fatigue and Boredom
JUL 05, 2021
ADHD Drug Reduces Daydreaming, Fatigue and Boredom
Researchers led by New York University have found that a stimulant drug may be able to treat persistent daydreaming, fat ...
JUL 05, 2021
Neuroscience
People with Autism More Likely to Self-Medicate with Recreational Drugs
JUL 05, 2021
People with Autism More Likely to Self-Medicate with Recreational Drugs
Researchers from the University of Cambridge have found that people with autism are more likely than people without the ...
JUL 07, 2021
Cannabis Sciences
Experts Reach Consensus on Dosing Cannabis for Chronic Pain
JUL 07, 2021
Experts Reach Consensus on Dosing Cannabis for Chronic Pain
Twenty cannabis experts from across the globe have reached a consensus on how medical cannabis may be used to treat chro ...
JUL 18, 2021
Neuroscience
How Slime Molds Think Without a Brain
JUL 18, 2021
How Slime Molds Think Without a Brain
A brainless slime mold known as Physarum polycephalum uses its body to sense mechanical cues in its environment. Then, i ...
Loading Comments...