APR 02, 2015 8:42 AM PDT

Clues into Cognitive Dysfunction in Chronic Fatigue Syndrome

WRITTEN BY: Ilene Schneider
Scientists at Columbia University's Mailman School of Public Health have identified a unique pattern of immune molecules in the cerebrospinal fluid of people with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) that provides insights into the basis for cognitive dysfunction-frequently described by patients as "brain fog"-as well as new hope for improvements in diagnosis and treatment.
Mady Hornig, MD, professor of Epidemiology at Columbia University's Mailman School of Public Health
In the study published in Molecular Psychiatry, Mady Hornig, MD, and colleagues used immunoassay testing methods to measure the levels of 51 immune biomarkers called cytokines in the cerebrospinal fluid of 32 people with ME/CFS for an average of seven years, 40 with multiple sclerosis, and 19 non-diseased controls. The researchers found that levels of most cytokines, including the inflammatory immune molecule, interleukin 1, were depressed in individuals with ME/CFS compared with the other two groups, matching what was seen in the blood study in patients who had the disease for more than three years. One cytokine-eotaxin-was elevated in the ME/CFS and MS groups, but not in the control group.

"We now know that the same changes to the immune system that we recently reported in the blood of people with ME/CFS with long-standing disease are also present in the central nervous system," says Dr. Hornig, professor of Epidemiology and director of translational research at the Center for Infection and Immunity at the Mailman School. "These immune findings may contribute to symptoms in both the peripheral parts of the body and the brain, from muscle weakness to brain fog."

Implications for Diagnosis and Treatment

"Diagnosis of ME/CFS is now based on clinical criteria. Our findings offer the hope of objective diagnostic tests for disease as well as the potential for therapies that correct the imbalance in cytokine levels seen in people with ME/CFS at different stages of their disease," adds W. Ian Lipkin, MD, John Snow Professor of Epidemiology and director of the Center for Infection and Immunity. There is precedent for use of human monoclonal antibodies that regulate the immune response in a wide range of disorders from rheumatoid arthritis to multiple sclerosis. However, the researchers note, additional work will be needed to assess the safety and efficacy of this approach.

Source: Columbia University
About the Author
  • Ilene Schneider is the owner of Schneider the Writer, a firm that provides communications for health care, high technology and service enterprises. Her specialties include public relations, media relations, advertising, journalistic writing, editing, grant writing and corporate creativity consulting services. Prior to starting her own business in 1985, Ilene was editor of the Cleveland edition of TV Guide, associate editor of School Product News (Penton Publishing) and senior public relations representative at Beckman Instruments, Inc. She was profiled in a book, How to Open and Operate a Home-Based Writing Business and listed in Who's Who of American Women, Who's Who in Advertising and Who's Who in Media and Communications. She was the recipient of the Women in Communications, Inc. Clarion Award in advertising. A graduate of the University of Pennsylvania, Ilene and her family have lived in Irvine, California, since 1978.
You May Also Like
NOV 02, 2021
Technology
Mini Sensors Help Detect Neuromotor Abnormalities in Infants
NOV 02, 2021
Mini Sensors Help Detect Neuromotor Abnormalities in Infants
Neuromotor abnormalities (such as abnormal movement and gross motor abilities) are often caused by often unseen damage t ...
NOV 01, 2021
Cell & Molecular Biology
Is This Closed Barrier Why Psychiatric & Bowel Disorders are Linked?
NOV 01, 2021
Is This Closed Barrier Why Psychiatric & Bowel Disorders are Linked?
Inflammatory bowel disease (IBD) is a term that describes chronic gut inflammation and includes ulcerative colitis and C ...
DEC 06, 2021
Genetics & Genomics
IBS and Depression Have Genetic Risk Factors in Common
DEC 06, 2021
IBS and Depression Have Genetic Risk Factors in Common
Irritable bowel syndrome (IBS) is a common condition around the world, and it can cause bloating, abdominal pain, and dy ...
DEC 23, 2021
Cell & Molecular Biology
Toxoplasma Parasites Can Manipulate Host Brain Cells
DEC 23, 2021
Toxoplasma Parasites Can Manipulate Host Brain Cells
The parasite that causes Toxoplasmosis, Toxoplasma gondii is common, and is found in undercooked or contaminated meat, a ...
JAN 13, 2022
Neuroscience
This is your brain on music: Goosebumps or meh?
JAN 13, 2022
This is your brain on music: Goosebumps or meh?
Neuroscientists uncover neural basis of emotional responses to music
JAN 19, 2022
Genetics & Genomics
Targeting Proteins Linked to Huntington's & ALS With a New Gene Editing Tool
JAN 19, 2022
Targeting Proteins Linked to Huntington's & ALS With a New Gene Editing Tool
The CRISPR gene editing tool is often used with an enzyme called Cas9, which targets and cuts genomic DNA. While this te ...
Loading Comments...