APR 02, 2015 08:42 AM PDT

Clues into Cognitive Dysfunction in Chronic Fatigue Syndrome

Scientists at Columbia University's Mailman School of Public Health have identified a unique pattern of immune molecules in the cerebrospinal fluid of people with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) that provides insights into the basis for cognitive dysfunction-frequently described by patients as "brain fog"-as well as new hope for improvements in diagnosis and treatment.
Mady Hornig, MD, professor of Epidemiology at Columbia University's Mailman School of Public Health
In the study published in Molecular Psychiatry, Mady Hornig, MD, and colleagues used immunoassay testing methods to measure the levels of 51 immune biomarkers called cytokines in the cerebrospinal fluid of 32 people with ME/CFS for an average of seven years, 40 with multiple sclerosis, and 19 non-diseased controls. The researchers found that levels of most cytokines, including the inflammatory immune molecule, interleukin 1, were depressed in individuals with ME/CFS compared with the other two groups, matching what was seen in the blood study in patients who had the disease for more than three years. One cytokine-eotaxin-was elevated in the ME/CFS and MS groups, but not in the control group.

"We now know that the same changes to the immune system that we recently reported in the blood of people with ME/CFS with long-standing disease are also present in the central nervous system," says Dr. Hornig, professor of Epidemiology and director of translational research at the Center for Infection and Immunity at the Mailman School. "These immune findings may contribute to symptoms in both the peripheral parts of the body and the brain, from muscle weakness to brain fog."

Implications for Diagnosis and Treatment

"Diagnosis of ME/CFS is now based on clinical criteria. Our findings offer the hope of objective diagnostic tests for disease as well as the potential for therapies that correct the imbalance in cytokine levels seen in people with ME/CFS at different stages of their disease," adds W. Ian Lipkin, MD, John Snow Professor of Epidemiology and director of the Center for Infection and Immunity. There is precedent for use of human monoclonal antibodies that regulate the immune response in a wide range of disorders from rheumatoid arthritis to multiple sclerosis. However, the researchers note, additional work will be needed to assess the safety and efficacy of this approach.

Source: Columbia University
About the Author
  • Ilene Schneider is the owner of Schneider the Writer, a firm that provides communications for health care, high technology and service enterprises. Her specialties include public relations, media relations, advertising, journalistic writing, editing, grant writing and corporate creativity consulting services. Prior to starting her own business in 1985, Ilene was editor of the Cleveland edition of TV Guide, associate editor of School Product News (Penton Publishing) and senior public relations representative at Beckman Instruments, Inc. She was profiled in a book, How to Open and Operate a Home-Based Writing Business and listed in Who's Who of American Women, Who's Who in Advertising and Who's Who in Media and Communications. She was the recipient of the Women in Communications, Inc. Clarion Award in advertising. A graduate of the University of Pennsylvania, Ilene and her family have lived in Irvine, California, since 1978.
You May Also Like
OCT 23, 2018
Cannabis Sciences
OCT 23, 2018
Does Marijuana Help or Hinder Stroke Recovery?
A recent study reported in the Journal of Stroke and Cerebrovascular Diseases has found that marijuana smokers have a higher rate of hospital adm...
NOV 26, 2018
Neuroscience
NOV 26, 2018
Ventromedial Prefrontal Cortex Central For Imagination Mitigated Fear
Extinction; presenting fear in a neutral setting where the negative consequences are negated is one of the successful fear conditioning mechanisms...
DEC 03, 2018
Neuroscience
DEC 03, 2018
Brain size and Intelligence
Identifying the connection between the brain size to smartness has become much more plausible due to accuracy in estimating the brain size by using technologically advanced neuroimaging metho...
DEC 13, 2018
Genetics & Genomics
DEC 13, 2018
Insights Into the Mechanisms Underlying Anxiety
Up to 40 million Americans have an anxiety disorder in any given year, and it's thought that only about a third get treatment....
DEC 17, 2018
Health & Medicine
DEC 17, 2018
Light Makes An Itch Go Away!
EMBL researchers have now found a way to stop itch with light in mice. Nature Biomedical Engineering publishes their results on 17 December 2018....
DEC 26, 2018
Technology
DEC 26, 2018
Advanced Computer System Based on Human Visual Learning
In a study published in the Proceedings of the National Academy of Sciences, a team of researchers have engineered an advanced computer system by basing it...
Loading Comments...