MAR 14, 2020 5:45 PM PDT

Mass Cytometry Can Bring New Cancer Therapeutics

WRITTEN BY: Nouran Amin

New technology may soon accelerate cancer therapeutic development. The revolutionary technique is called mass cytometry (also referred to as CyTOF) and can reveal the inner workings of individual cancer cells. The technology can help identify different cancer markers that respond to diverse anti-cancer medications—suggesting new treatment combinations.

Learn more about cancer cells:

"We wanted to better understand the molecular differences between individual cancer cells so we could discover how these differences impact the cancer's response to therapies -- for example, whether some cells are more resistant than other anti-cancer drugs," Dr. Charis Teh , one of the study lead authors. "We decided that a new technology, called mass cytometry, would be an ideal approach to address this question."

CyTOF was demonstrated on blood cancer cells taken from myeloma patients samples and revealed the suitability of some ‘biomarkers’ in treating patients most effectively.

"The system we developed simultaneously and precisely measures 26 separate proteins in a blood cancer cell line derived from myeloma -- an incurable cancer of immune B cells," Dr Teh said. "We focused on understanding why some cells are sensitive to anti-cancer agents, while others are resistant.

Researchers found a protein-- MCL-1—that can prevent cell death and is believed to be a key factor for determining whether cells have lived or died when exposed to certain drugs like dexamethasone or bortezomib.

"Excitingly, there are already drugs in clinical trials that inhibit MCL-1 -- and when we tested these against myeloma cells, we found the MCL-1 inhibitor made the cells more sensitive to dexamethasone. This was even the case in myeloma samples taken from a patient -- our system had identified a potential new therapeutic approach for myeloma," Dr Teh said.

Source: Science Daily

About the Author
Master's (MA/MS/Other)
Nouran is a scientist, educator, and life-long learner with a passion for making science more communicable. When not busy in the lab isolating blood macrophages, she enjoys writing on various STEM topics.
You May Also Like
DEC 16, 2022
Infographics
Geothermal Energy
Geothermal Energy
In an age of renewables, geothermal energy is an excellent way for humanity to slowly wean itself off fossil fuels. Usin ...
JAN 07, 2023
Coronavirus
Four Major Types of Long COVID Emerge
Four Major Types of Long COVID Emerge
Even mild cases of COVID-19 can lead to long COVID, in which symptoms linger for weeks, months, or longer, significantly ...
JAN 12, 2023
Space & Astronomy
"Bright Spots" of Ceres | Solar System Wonders
"Bright Spots" of Ceres | Solar System Wonders
The eight planets and 200-plus moons that populate our solar system aren't the only locations that exhibit awe-inspiring ...
JAN 18, 2023
Technology
Artificial pancreas for type 2 diabetes management
Artificial pancreas for type 2 diabetes management
Type 2 diabetes is an increasingly common condition around the globe, affecting over 400 million people. In type 2 diabe ...
JAN 15, 2023
Earth & The Environment
Renewable Materials Converted into Household Items Via Catalyst
Renewable Materials Converted into Household Items Via Catalyst
In a recent study published in the Journal of the American Chemical Society Gold (JACS Au), a team of researchers led by ...
JAN 29, 2023
Chemistry & Physics
Will the Supervolcano in Yellowstone Erupt Soon?
Will the Supervolcano in Yellowstone Erupt Soon?
Beneath the beauty of Yellowstone National Park exists a massive volcano that last erupted 70,000 years ago. The media o ...
Loading Comments...