AUG 06, 2017 4:15 PM PDT

A Novel Glioblastoma Therapy

WRITTEN BY: Carmen Leitch

Glioblastoma is a type of aggressive brain tumor, and while it is rare, it's still the most common malignant primary brain tumor in adults, developing from glial cells called astrocytes. There are no potent treatment options for this disease, but researchers have been working to find one. Recent work, however, has revealed a possible new drug target for individuals with glioblastoma.

That target is tyrosine phosphatase receptor type Z or PTPRZ. Scientists at the National Institute for Basic Biology, NIBB, found that PTPRZ is important to stem cell maintenance as well as affecting malignancy in glioblastoma cells. Their work indicated that inhibition of PTPRZ could suppress tumor growth in C6 glioblastoma cells in mouse models. Additionally, the PTPRZ inhibitor NAZ2329 reduced tumor growth in cell culture models and C6 glioblastoma xenografts.

Learn more about the work, which was published in Scientific Reports, from the video. The new data could eventually benefit those diagnosed with glioblastoma, a disease that has a median survival rate of only 14 months.
About the Author
BS
Experienced research scientist and technical expert with authorships on over 30 peer-reviewed publications, traveler to over 70 countries, published photographer and internationally-exhibited painter, volunteer trained in disaster-response, CPR and DV counseling.
You May Also Like
DEC 10, 2020
Plants & Animals
3M Helps Solve Polar Bear Tracking Problem
DEC 10, 2020
3M Helps Solve Polar Bear Tracking Problem
As climate change continues to alter the Arctic landscape, polar bear research becomes more urgent. Observing animals in ...
JAN 04, 2021
Space & Astronomy
Did Intelligent Civilizations Roam Our Galaxy 5 Billion Years Ago?
JAN 04, 2021
Did Intelligent Civilizations Roam Our Galaxy 5 Billion Years Ago?
Researchers have found that there were likely many intelligent alien civilizations sprawled across our galaxy billions o ...
JAN 08, 2021
Neuroscience
Brain Scans Show Why Comedy-News Shows are More Memorable
JAN 08, 2021
Brain Scans Show Why Comedy-News Shows are More Memorable
Comedy-news shows such as those by Trevor Noah, John Oliver, and Samantha Bee on the rise and are especially popular amo ...
MAR 05, 2021
Plants & Animals
Scientists Heal Diseased Corals
MAR 05, 2021
Scientists Heal Diseased Corals
The world's coral reefs face numerous threats, including climate change, pollution, and habitat loss. Since 2014, an ...
APR 01, 2021
Space & Astronomy
Astronomers Detect X-rays from Uranus for First Time
APR 01, 2021
Astronomers Detect X-rays from Uranus for First Time
Until now, astronomers had detected X-rays from every planet in our solar system apart from the two Ice Giants: Uranus a ...
OCT 15, 2021
Health & Medicine
The Art of the Smize: Study Shows Eyes are More Active in Smiling Behind a Mask
OCT 15, 2021
The Art of the Smize: Study Shows Eyes are More Active in Smiling Behind a Mask
Mask wearing has become a part of our everyday lives. Something that we have all adapted to because of this is expressin ...
Loading Comments...