JUL 10, 2018 5:18 PM PDT

New Tools in the CRISPR Kit

WRITTEN BY: Carmen Leitch

Some genetic diseases are more straightforward than others. In cases like cystic fibrosis or Marfan syndrome, a mutation makes a gene defective, and that causes symptoms in a patient that are characterized as a disease. But other kinds of genetic diseases can involve a complex interplay of genes and sometimes, environmental factors, that all work together to create symptoms in a patient. Heart disease and type 2 diabetes are examples of complex diseases.

When using a tool like CRISPR, making a single gene edit can be all that’s necessary to produce or rescue a disease phenotype, but for studying complex diseases a more refined tool is needed. Scientists at UCSF created altered versions of CRISPR so that genes can be manipulated in other ways; CRISPRi can lower gene expression levels, and CRISPRa can activate genes, as explained in the video.

About the Author
BS
Experienced research scientist and technical expert with authorships on over 30 peer-reviewed publications, traveler to over 70 countries, published photographer and internationally-exhibited painter, volunteer trained in disaster-response, CPR and DV counseling.
You May Also Like
NOV 06, 2020
Space & Astronomy
300 Million Planets in the Milky Way May Be Habitable
NOV 06, 2020
300 Million Planets in the Milky Way May Be Habitable
Researchers have found that there could be at least 300 million habitable worlds in the Milky Way galaxy. This could mea ...
FEB 19, 2021
Plants & Animals
Group of Migrating Gray Whales Makes a Puget Sound Pitstop
FEB 19, 2021
Group of Migrating Gray Whales Makes a Puget Sound Pitstop
Washington’s Puget Sound is famously home to resident and transient orca pods. However, during their yearly migrat ...
MAR 26, 2021
Plants & Animals
A Massive 17-Year Cicada Swarm will Emerge Soon
MAR 26, 2021
A Massive 17-Year Cicada Swarm will Emerge Soon
The east coast is preparing for one of nature’s greatest spectacles. A gigantic swarm of periodical cicadas is due ...
JUN 24, 2021
Space & Astronomy
European Space Agency to Launch Satellite Made from Plywood
JUN 24, 2021
European Space Agency to Launch Satellite Made from Plywood
Modern spacecraft are typically made out of carbon fiber composites. Now, however, the European Space Agency has announc ...
JUL 05, 2021
Plants & Animals
Why Are Some Fish Warm-Blooded? A Need for Speed
JUL 05, 2021
Why Are Some Fish Warm-Blooded? A Need for Speed
Great white sharks are warm-blooded, and new research helps explain why.
JUL 22, 2021
Space & Astronomy
Telescope Riding a Balloon Could Replace Hubble
JUL 22, 2021
Telescope Riding a Balloon Could Replace Hubble
The Earth's atmosphere often muffles views from ground-based telescopes when observing space. Now, a research c ...
Loading Comments...