The skin is the body's primary barrier against physical insults and microbial pathogens. It represents a unique environment in which cells of the immune system interact with skin cells to maintain tissue homeostasis and induce immune responses. Diverse and functionally specialized subsets of cells of the immune system sense and respond to infection or various barrier breaches to activate an immune response and eventually return to homeostasis. However, deregulated immune responses can also cause skin disorders such as psoriasis. This animated video introduces the environment and key participants in skin immunity in the steady state and disease.
Animation by Arkitek Scientific.