JUN 26, 2016 08:31 AM PDT

"Gut Reaction" - Another Winner From Koch Awards 2016

WRITTEN BY: Carmen Leitch

Jatin Roper is a gastroenterologist who works in the laboratory of Omer Yilmaz, an Assistant Professor of Biology at Massachusetts Institute of Technology (MIT). An image Roper submitted to the Koch Awards at MIT is described here in the latest video highlighting the winners.

This lab studies how factors like obesity and aging influence tumor growth in colorectal cancer, the third most common cause of cancer death. While there are mouse models they can use for their work, there are limitations to using them; they don't accurately represent disease in humans patients and they are time consuming to work with.

As a solution to these problems, the researchers created organoids - cells in 3D culture. These cells also aren't perfect representations of disease; they lack the surrounding intestinal environment. The scientists found a way to combine these two models. The result is shown in the winning microscopy image; a mouse colon is seen containing transplanted organoids - in pink - that have grown into the colon. These cells are fully functional in the new mouse colon.

This new methodology enables previously impossible experiments. The team plans to use CRISPR gene editing both in the colon and organoids to investigate the role various genes play in tumor development, to analyze how obesity affects normal tissue and causes cancer, and to understand the pathways involved. Hopefully this knowledge translates into improvements for patient therapy.
About the Author
  • Experienced research scientist and technical expert with authorships on 28 peer-reviewed publications, traveler to over 60 countries, published photographer and internationally-exhibited painter, volunteer trained in disaster-response, CPR and DV counseling.
You May Also Like
JUL 09, 2018
Videos
JUL 09, 2018
Does Microwaving Food Affect It's Nutritional Value?
  Microwaving is a convenient way to heat food with ease and in short periods of time. But, do microwaves change the nutritional value of food? Microw...
AUG 02, 2018
Videos
AUG 02, 2018
CBD and THC Effects on the Brain
What has similar chemical make-ups but different structures? CBD and THC. In the video below, learn more about how THC (tetrahydrocannabinol) and CBD (Cann...
AUG 11, 2018
Videos
AUG 11, 2018
How Is Sugar Extracted?
How is sugar extracted? Well, sugar is extracted from a root vegetable, the sugar beet. However, the whole extraction process is a precise procedure that i...
AUG 13, 2018
Videos
AUG 13, 2018
One Cell was Consumed by Another in a Evolutionary Leap
A process called endosymbiosis may have given evolution a lot of help....
AUG 16, 2018
Chemistry & Physics
AUG 16, 2018
A-bombs Were More Powerful Than First Estimated
The atomic age gave birth to a pair of unlikely twins: onet being nuclear reactor technology that supplies us low-carbon energy and life-saving radioisotop...
AUG 21, 2018
Videos
AUG 21, 2018
Moody or a Mental Illness?
Parenting is not easy. Sometimes a child's behavior might mean that there is a mental health issue or it could be just a kid having a bad day. Between...
Loading Comments...