NOV 09, 2018 09:00 AM CST
Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar

NMR in standardizing biomarkers for personalized medicine: Where do biobanks come in?

SPONSORED BY: Bruker
C.E. CREDITS: P.A.C.E. CE | Florida CE
Speakers
  • Universitätsmedizin Greifswald, Institut für Klinische Chemie und Laboratoriumsmedizin, Ferdinand-Sauerbruch-Straße, 17475 Greifswald
    Biography
      Prof. Matthias Nauck, born 1961, completed his medical studies at the University Hospital Freiburg. In 1997 he became specialist for laboratory medicine after obtaining his doctorate in 1992. He received his habilitation in 2000 and since 2002 Prof. Nauck is director of the Institute of Clinical Chemistry and Laboratory Medicine at the University Medicine Greifswald.

    Abstract:
    DATE: November 9, 2018
    TIME: 9:00am CST, 10:00am JST, 12:00pm AEDT
     
    Personalized and precision medicine are rapidly growing areas that require high quality spectral as well as metadata to categorize patients. Standardized spectral data are key to identify biomarkers or patterns of multiple biomarkers. Correct description of the natural variation in body fluids of healthy cohorts is the basis to correct outlier signal identification describing deviations from normality. Giving access to a large number of samples and spectroscopy data thereof is a task, that can be fulfilled by biobanks.  Based on the reproducibility and transferability of nuclear magnetic resonance (NMR) multiple biobanks under standardization can deliver NMR spectra instead of Aliquots, to be used in clinical trials or clinical and translational research. Such NMR spectra can in first place be used for extensive quality control of biobank specimens and creating large amounts of quantification results e.g. in plasma/serum and urine. Such results can be stored with the metadata for each sample.
     
    The Bruker IVDr Platform and embedded solutions for biobanking will be shortly introduced before Prof Nauck takes over and presents results obtained analyzing plasma/serum and urine NMR-spectral data generated under fully standardized condition in targeted and untargeted mode. It will also be shown how lipoprotein subclass analysis and small molecule quantification in plasma/serum as well as quantification of urinary metabolites can support the development of diagnostic routines.
     
    In addition, Prof. Nauck will highlight the need for high quality biobanking and the benefit of applying NMR analysis on biobank specimen. Providing access to fully standardized spectra produced as part of the biobank QC forms a major contribution to clinical and translational research.
     
    Viewers can expect to see the following key topics:
     
    • Saving time and cost by providing NMR spectra under standardized conditions from each biobank sample as part of the QC and storing them into the biobank together with quantification results. Biobank clusters using the standardized NMR approach will rapidly grow, providing exchangeable spectra.
    • Development of potential new diagnostic methods under standardized NMR conditions, be it in precision medicine or using epidemiological approaches.
     
    Who should attend:
     
    The webinar will be of interest to biobanks, hospitals that have biorepositories, pharmaceutical companies in development and clinical trials, epidemiologist and laboratories that are interested in optimizing NMR spectroscopic techniques methods, which can contribute to a system biology approach.
     

    Show Resources
    You May Also Like
    MAY 22, 2018 08:00 AM PDT
    C.E. CREDITS
    MAY 22, 2018 08:00 AM PDT
    DATE: May 22, 2018TIME: 08:00AM PDT The nuclear receptors pregnane X receptor (PXR) and constitutive androstane receptor (CAR) are closely related transcription factors that...
    APR 27, 2018 10:00 AM PDT
    C.E. CREDITS
    APR 27, 2018 10:00 AM PDT
    DATE: April 27, 2018TIME: 10:00am PST, 1:00pm ESTGlioblastoma (GBM) and Medulloblastoma (MB) are the most common adult and paediatric brain tumours, both of which can have devastating c...
    MAY 03, 2018 11:00 AM PDT
    MAY 03, 2018 11:00 AM PDT
    DATE: May 3, 2018TIME: 11:00AM PDT, 2:00PM EDTWhile stress is one of the leading causes of neuropsychiatric disorders, the molecular underpinnings of how stress induces alterations in b...
    MAY 24, 2018 09:30 AM PDT
    C.E. CREDITS
    MAY 24, 2018 09:30 AM PDT
    DATE: May 24, 2018 TIME: 9:30PM PDT The current gold standard in in vitro pre-clinical cancer treatment screening remain cell lines,...
    JUN 29, 2018 09:00 AM PDT
    C.E. CREDITS
    JUN 29, 2018 09:00 AM PDT
    DATE: June 29, 2018TIME: 09:00AM PDT, 12:00PM EDT There is significant epidemiological evidence to suggest that the consumption of a high-broccoli diet is associated with a r...
    AUG 15, 2018 08:00 AM PDT
    C.E. CREDITS
    AUG 15, 2018 08:00 AM PDT
    DATE: August 15, 2018TIME: 08:00AM PDT, 11:00AM EDTThe failure of current chemotherapeutic strategies in the fight against cancer can be largely attributed to the occurrence of drug res...
    Loading Comments...