SEP 20, 2018 8:00 AM PDT

Cardiovascular Disease: Applying MRI to study atherosclerosis, the aortic arch and endothelial permeability in small animal models

Speaker

Abstract
DATE: September 20, 2018
TIME: 11:00am EDT, 5:00pm CEST
 
Cardiovascular disease due to atherosclerosis is the leading cause of disease and mortality worldwide. So-called “vulnerable” atherosclerotic plaques are those that are likely to result in clinical events. One of the hallmarks of vulnerable plaques is increased endothelial permeability, a feature that is related to the progression of the disease across all stages of the atherosclerotic cascade.
 
Increased endothelial permeability at the beginning of atherosclerosis is believed to allow lipid deposition and plaque formation to occur. At later stages it is associated with plaque inflammation and extravasation of inflammatory cells that occurs as a plaque progresses and may eventually lead to plaque rupture. This webinar will describe the application of magnetic resonance imaging (MRI) for the characterization of increased endothelial permeability in mouse atherosclerotic plaques using the preclinical Bruker Biospec 7 Tesla horizontal 70/30 scanner and self-gating features (IntraGate). Self-gated imaging allows high-quality cardiac MRI with no additional hardware requirements (such as the use of ECG electrodes) and potential pitfalls of signal interferences and disruption and has been used in our laboratory to obtain clear imaging of the mouse aortic root.
 
The basics self-gated imaging, along with the advantages of applying this method in both cardiac and vascular MRI, will be discussed.  For example, this flexible tool allows high quality, high resolution pre-clinical cardiac and vascular imaging without the need for ECG triggering, meaning no electrodes and no gating with a device is needed.
 
Key topics
 
  • Applying MRI to study atherosclerosis in the mouse aortic root, with a focus on endothelial permeability
  • 2D dynamic contrast enhanced (DCE) MRI and 3D T1 mapping of the aortic root and ascending aorta using Bruker BioSpec 70/30 USR and self-gated imaging (IntraGate software package)
  • The advantages of using self-gated techniques for cardiac and vascular imaging
  • The flexibility these techniques provide for individuals working in pre-clinical imaging
 
Who should attend?
 
The webinar will be useful to anybody interested in cardiac and vascular imaging of small animals, particularly using MRI. It would also be useful for researchers who image larger animals on clinical scanners but who are interested in smaller animal imaging where more in-depth mechanistic studies can be conducted. The webinar will also appeal to anyone interested in the pathology of cardiovascular disease.

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SEP 20, 2018 8:00 AM PDT

Cardiovascular Disease: Applying MRI to study atherosclerosis, the aortic arch and endothelial permeability in small animal models



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