SEP 20, 2018 8:00 AM PDT

Cardiovascular Disease: Applying MRI to study atherosclerosis, the aortic arch and endothelial permeability in small animal models

Sponsored by: Bruker

DATE: September 20, 2018
TIME: 11:00am EDT, 5:00pm CEST
Cardiovascular disease due to atherosclerosis is the leading cause of disease and mortality worldwide. So-called “vulnerable” atherosclerotic plaques are those that are likely to result in clinical events. One of the hallmarks of vulnerable plaques is increased endothelial permeability, a feature that is related to the progression of the disease across all stages of the atherosclerotic cascade.
Increased endothelial permeability at the beginning of atherosclerosis is believed to allow lipid deposition and plaque formation to occur. At later stages it is associated with plaque inflammation and extravasation of inflammatory cells that occurs as a plaque progresses and may eventually lead to plaque rupture. This webinar will describe the application of magnetic resonance imaging (MRI) for the characterization of increased endothelial permeability in mouse atherosclerotic plaques using the preclinical Bruker Biospec 7 Tesla horizontal 70/30 scanner and self-gating features (IntraGate). Self-gated imaging allows high-quality cardiac MRI with no additional hardware requirements (such as the use of ECG electrodes) and potential pitfalls of signal interferences and disruption and has been used in our laboratory to obtain clear imaging of the mouse aortic root.
The basics self-gated imaging, along with the advantages of applying this method in both cardiac and vascular MRI, will be discussed.  For example, this flexible tool allows high quality, high resolution pre-clinical cardiac and vascular imaging without the need for ECG triggering, meaning no electrodes and no gating with a device is needed.
Key topics
  • Applying MRI to study atherosclerosis in the mouse aortic root, with a focus on endothelial permeability
  • 2D dynamic contrast enhanced (DCE) MRI and 3D T1 mapping of the aortic root and ascending aorta using Bruker BioSpec 70/30 USR and self-gated imaging (IntraGate software package)
  • The advantages of using self-gated techniques for cardiac and vascular imaging
  • The flexibility these techniques provide for individuals working in pre-clinical imaging
Who should attend?
The webinar will be useful to anybody interested in cardiac and vascular imaging of small animals, particularly using MRI. It would also be useful for researchers who image larger animals on clinical scanners but who are interested in smaller animal imaging where more in-depth mechanistic studies can be conducted. The webinar will also appeal to anyone interested in the pathology of cardiovascular disease.

Show Resources
You May Also Like
MAY 11, 2021 10:00 AM PDT
MAY 11, 2021 10:00 AM PDT
Date: May 11, 2021 Time: 10:00zm PDT Your samples are some of the most valuable assets in the laboratory. After spending countless hours on extraction and preparation, your conclusions could...
SEP 14, 2021 7:00 AM PDT
SEP 14, 2021 7:00 AM PDT
Date: September 14, 2021 Time: 7am PDT, 10am EDT, 4pm CEST A conventional thermal cycler has long been a commodity product in the lab and end-point PCR techniques can be completed almost wit...
JUN 09, 2021 7:00 AM PDT
JUN 09, 2021 7:00 AM PDT
Date: June 9, 2021 Time: 09 June 2021, 7am PDT, 10am EDT, 4pm CEST cells with dramatic implications on the validity of past cell culture related research. The fact that at least 509 cell lin...
APR 01, 2021 8:00 AM PDT
APR 01, 2021 8:00 AM PDT
Date: April 01, 2021 Time: 8:00am (PST), 11:00am (EST) Generating therapeutic antibodies is far more challenging than obtaining antibodies that merely recognize their targets. Engineering po...
OCT 27, 2021 8:00 AM PDT
OCT 27, 2021 8:00 AM PDT
Date: October 27, 2021 Time: 8:00am (PDT), 11:00am (EDT) Learn about how brightfield images can take your flow cytometry data to the next level. Join Dr. Cora Chadick, Technical Director, as...
APR 21, 2021 5:00 PM CEST
APR 21, 2021 5:00 PM CEST
Date: April 21, 2021 Time: 8:00am (PDT), 11:00am (EDT), 5:00pm (CEST) Spatial Answers Trilogy - Spatial Answers in Immunology Immunology Researchers share their Spatial Discoveries in SARS-C...
SEP 20, 2018 8:00 AM PDT

Cardiovascular Disease: Applying MRI to study atherosclerosis, the aortic arch and endothelial permeability in small animal models

Sponsored by: Bruker


Cancer Research


Molecular Biology


Cell Biology



Laboratory Testing

Cancer Diagnostics

Clinical Diagnostics

Clinical Chemistry






North America54%




South America2%


Registration Source

Website Visitors74%

WAVE Newsletter Promotion9%

Email Promotions6%

Social Media Promotions5%

Website Banners1%

Trending Newsletter Promotion1%


Job Title


Medical Laboratory Technician17%



Facility/Department Manager9%

Research Scientist9%

Medical Doctor/Specialist7%

Clinical Laboratory Scientist6%


Lab Management4%

Post Doc2%


Academic Institution24%


Clinical Laboratory6%


Research Institute6%

Biotech Company6%

Medical School6%

Pharmaceutical Company4%

Life Science Company4%

Medical Device Company2%

Industrial Company1%

Animal Hospital1%

Medical Center1%



Show Resources
Loading Comments...
Show Resources