Acoustic Ejection Mass Spectrometry for High-Throughput Analysis

C.E. Credits: P.A.C.E. CE Florida CE
Speaker
  • Senior Staff Engineer, 
Research & Development
    Biography
      Lucien Ghislain is technology access program manager and senior staff engineer at Beckman Coulter Life Sciences (formerly Labcyte) in San Jose, CA. He engages in advanced development of high-impact analytical instrumentation leveraging the novel integration of diverse technologies. This includes collaborative research and innovation, proof-of-concept demonstration, system design and integration, early customer evaluation and commercial product development. Lucien earned his Ph.D. from Cornell University and has worked at Labcyte in various roles for fourteen years.

    Abstract

    We describe a mass spectrometry (MS) analytical platform resulting from the novel integration of acoustic droplet ejection (ADE) technology, an open-port interface (OPI), and electrospray ionization (ESI) MS that creates a transformative system enabling high-speed sampling and label-free analysis. The ADE technology delivers nanoliter droplets in a touchless manner with high speed, precision and accuracy; subsequent sample dilution within the OPI, in concert with the capabilities of modern ESI-MS, eliminates the laborious sample preparation and method development required in current approaches. This platform is applied to a variety of experiments, including high-throughput (HT) pharmacology screening, label-free in situ enzyme kinetics, in vitro and in vivo adsorption, distribution, metabolism, elimination, pharmacokinetic (PK) and biomarker analysis, and HT parallel medicinal chemistry.

    Learning Objectives:

    1. Explain the front-end separation bottleneck to high-throughput mass spectrometry

    2. How to achieve 50X faster mass spectrometry sample analysis with no compromise in data quality


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