MAY 10, 2017 1:30 PM PDT

Addressing "NGS Dead Zones" with Third-Generation PacBio Sequencing

Sponsored by: PacBio
Speaker
  • Chief Scientific Officer, Pacific Biosciences
    Biography
      Jonas Korlach was appointed Chief Scientific Officer of Pacific Biosciences in July 2012. He was previously a Scientific Fellow, supporting commercial development of the PacBio RS II system and performing research aimed at developing new applications for SMRT technologies. He co-invented the SMRT technology with Stephen Turner, Ph.D., Pacific Biosciences Founder and Chief Technology Officer, when the two were graduate students at Cornell University.

      Dr. Korlach joined Pacific Biosciences as the company's eighth employee in 2004. Previously, he was a Postdoctoral Researcher at Cornell University. Dr. Korlach is the recipient of multiple grants, an inventor on 70 issued U.S. patents and 61 international patents, and an author of over 100 scientific studies on the principles and applications of SMRT technology, including publications in Nature, Science, and PNAS. In 2013, Dr. Korlach was honored by the Obama White House as an Immigrant Innovator "Champion of Change." He received both his Ph.D. and his M.S. degrees in Biochemistry, Molecular and Cell Biology from Cornell, and received M.S. and B.A. degrees in Biological Sciences from Humboldt University in Berlin, Germany.

    Abstract

    SMRT Sequencing is a DNA sequencing technology characterized by long read lengths and high consensus accuracy, regardless of the sequence complexity or GC content of the DNA sample. These characteristics can be harnessed to address medically relevant genes, mRNA transcripts, and other genomic features that are otherwise difficult or impossible to resolve. I will describe examples for such new clinical research in diverse areas, including full-length gene sequencing with allelic haplotype phasing, gene/pseudogene discrimination, sequencing extreme DNA contexts, high-resolution pharmacogenomics, biomarker discovery, structural variant resolution, full-length mRNA isoform cataloging, and direct methylation detection.


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    Addressing "NGS Dead Zones" with Third-Generation PacBio Sequencing

    Sponsored by: PacBio

    Specialty

    Diagnostics

    Gene Sequencing

    University

    Drug Discovery

    Mass Cytometry

    Cell Culture

    T-Cells

    Biotechnology

    Immunotherapeutics

    Antibodies

    Virology

    Genetics

    Immunology

    Research

    Dna Sequencing

    Geography

    Asia67%

    Europe33%

    Registration Source

    Website Visitors100%

    Job Title

    Student33%

    Medical Doctor/Specialist33%

    Medical Laboratory Technician33%

    Organization

    Clinical Laboratory33%

    Academic Institution33%

    Manufacturer - Other33%


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