FEB 27, 2019 1:30 PM PST

Advanced Liver Tissue Model for Improved in Vitro Prediction

Presented at: Drug Discovery 2019
Speaker

Abstract

Isolated hepatocytes or their enzymes comprise the basis of most in vitro DMPK and toxicity assays used to predict human hepatic outcomes. Because hepato-specific functions are typically lost in the first hours or days of culture in many in vitro hepatic models, such models are of limited use in instances where meaningfully predictive simulation of a compound’s properties require that the in vitro model maintain such function stably over longer time periods, such as where compounds clear slowly, where metabolites are generated over extended periods of time, where membrane polarization is required for biliary canalicular formation, or where cellular conditions may cumulate after repeated dosing, such as in cholestatic toxicities. To address this limitation, more advanced liver models have been developed and extensively characterized.  These long-term models have been shown to more accurately predict intrinsic clearance, metabolite generation, and toxicity profiles.

Learning Objectives:

1.  Learn about advanced liver models for improved in vitro prediction.  
2.  Learn about the next wave of organ-on-chip with microfluidic advancements.  


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FEB 27, 2019 1:30 PM PST

Advanced Liver Tissue Model for Improved in Vitro Prediction

Presented at: Drug Discovery 2019

Specialty

Cell

Research

Cancer Therapeutics

Animal Research

Research And Development

Life Science

Cancer

Molecular Biology

Laboratory Animal Sciences

Hepatology

Health

Cell Culture

Disease

Biotechnology

Animal Behavior

Geography

Asia71%

Europe29%

Registration Source

Website Visitors100%

Job Title

Research Scientist43%

Medical Doctor/Specialist14%

Executive14%

Medical Laboratory Technician14%

Scientist14%

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Pharmaceutical Company43%

Academic Institution29%

Manufacturer - Other14%

Research Institute14%


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