MENU

Advances in the Diagnosis of Primary Aldosteronism

Sponsored by: DiaSorin
Speakers

Abstract

Primary Aldosteronism (PA) is a group of disorders characterized by inappropriate aldosterone production. PA is commonly caused by an adrenal adenoma, or by hyperplasia of the adrenal zona glomerulosa that can be either unilateral or bilateral. The disorder accounts for up to 15% of total hypertensive patients making it a serious public health concern. Patients with PA have a higher cardiovascular morbidity and mortality risk when compared with those with essential hypertension matched for age, sex and blood pressure. Fortunately, timely diagnosis through laboratory testing leads to a potentially treatable or curable disorder. The Endocrine Society guidelines recommend a multi-tiered approach with both screening and provocative confirmatory testing for the diagnosis of PA. The guidelines recommend the plasma aldosterone/plasma renin ratio (ARR) as the most reliable screening test for PA. Traditionally, renin is measured by a plasma renin activity (PRA) radioimmunoassay or liquid chromatography tandem mass spectrometry (LC-MS/MS). However, newer quantitative renin mass immunoassays offer benefits of walk-away automation, better turnaround times and stability with comparable diagnostic accuracy to PRA.  In this webinar, we will discuss the updates to the Endocrine Society practice guidelines for the management of PA and present data from a large study assessing the diagnostic accuracy of different Renin assays to predict PA in hypertensive patients.

Learning Objectives:

  • Discuss the diagnostic algorithm for the work up of Primary Aldosteronism from the latest Endocrine Society Practice Guidelines
  • Identify the importance of screening for Primary Aldosteronism (PA) in patients with hypertension
  • Assess the diagnostic accuracy of the renin mass assay to predict PA among hypertensive patients

Show Resources
You May Also Like
SEP 14, 2021 7:00 AM PDT
C.E. CREDITS
SEP 14, 2021 7:00 AM PDT
Date: September 14, 2021 Time: 7am PDT, 10am EDT, 4pm CEST A conventional thermal cycler has long been a commodity product in the lab and end-point PCR techniques can be completed almost wit...
SEP 17, 2021 12:00 PM CST
C.E. CREDITS
SEP 17, 2021 12:00 PM CST
Date: September 16, 2021 Time: 9:00pm (PDT), 12:00am (EDT) 3D cellular models like organoids and spheroids offer an opportunity to better understand complex biology in a physiologically rele...
NOV 30, 2021 10:00 AM PST
C.E. CREDITS
NOV 30, 2021 10:00 AM PST
Date: November 30, 2021 Time: 10:00am (PDT), 1:00pm (EDT) The prevalence of thyroid disease worldwide has served as a catalyst for healthcare providers to study various tools and methods to...
OCT 20, 2021 10:00 AM PDT
C.E. CREDITS
OCT 20, 2021 10:00 AM PDT
Date: October 20, 2021 Time:10:00am (PDT), 1:00pm (EDT) As the prevalence of Diabetes continues to rise in many areas across the globe, healthcare providers continue to look for methods that...
NOV 09, 2021 11:00 AM PST
C.E. CREDITS
NOV 09, 2021 11:00 AM PST
Date: November 09, 2021 Time: 11:00am (PDT), 02:00pm (EDT) Clinical translation of human pluripotent stem cells (hPSCs) requires advanced strategies that ensure safe and robust long-term gro...
DEC 09, 2021 6:00 AM PST
C.E. CREDITS
DEC 09, 2021 6:00 AM PST
Date: December 9, 2021 Time: 6:00am (PDT), 9:00 am (EDT) As the number of biotherapeutic candidates in development is increasing, the requirements of analytical tools to understand the molec...
Loading Comments...
Show Resources