SEP 15, 2015 8:00 AM PDT

WEBINAR: Advances in Live Cell Imaging

Speakers
  • Director and Professor, School of Molecular Biosciences, Washington State University
    Biography
      Jonathan Jones is a native of Wales and has lived in the US since 1981. He received his undergraduate and master's degrees from the University of Cambridge, England, and a PhD from the University of St Andrews in Scotland. He undertook post-doctoral research at Carnegie-Mellon University in Pittsburgh and Northwestern University in Chicago. He joined the faculty at Northwestern in 1986 and achieved the rank of full professor in 1999. In 2013, Dr. Jones accepted the position of Director of the School of Molecular Biosciences at Washington State University in Pullman, WA. In Pullman Dr. Jones directs a research group studying the molecular basis of communication between cells and their environment and how this communication regulates homeostasis and repair of tissues. A particular focus of the group is on the interaction between epithelial cells and the laminin elements of the extracellular matrix. Since the 1980s the lab has been investigating the structure and function of the components of a matrix attachment device called the hemidesmosome found in skin and certain other epithelial tissue types. Current projects in the lab include investigating how laminin receptors of the hemidesmosome transduce signals both into and out of cells, how laminin matrices are assembled and understanding how the dynamics of hemidesmosome proteins determine directed migration in moving skin cells. These analyses involve modern cell and molecular techniques, in vitro and in vivo studies as well as high resolution light microscopical evaluation of fixed and live cells and tissues. Dr. Jones has authored more than 110 primary research papers and a number of highly cited reviews on cell junctions and laminins. Studies in the Jones lab have been funded by various funding agencies including the ACS, the AHA, the DOD and several institutes of the NIH.
    • Global Product Manager, Life Science Division, Leica Microsystems CMS GmbH
      Biography
        Jennifer Horner is Global Product Manager, Life Science Division, for widefield microscopy at Leica Microsystems CMS GmbH. In this role, she has been involved in the development and commercialization of the latest innovations in compound microscopy, including the Leica DMi8 inverted microscope, and works extensively with customers to find solutions to their unique needs for imaging in the life sciences. She received her Ph.D. in Biochemistry and Molecular Biology from the University of California, Davis where she studied the dynamics of mitochondrial division and fusion using a variety of both in vivo imaging techniques and in vitro characterization.
      • Product Manager Inverted Microscopes, Life Science Division, Leica Microsystems CMS GmbH
        Biography
          Bernard Kleine, Product Manager Inverted Microscopes, Life Science Division, Leica Microsystems in Wetzlar, studied Physics and Biophysics in Gießen, Germany. His major fields of activity are Image Analysis, Photometry, and Microscopy. He joined Leica 1983 as software application specialist. Bernard Kleine introduced the first image analysis systems within Leica Microsystems. He has been a product manger for Leica Live Science Research Inverted Microscopes since 1996.

        Abstract
        DATE: September 15, 2015
        TIME: 8:00AM PT, 11:00AM ET

        Skin Cell Motility: Integrins Lead the Way


        You will learn about efforts to dissect mechanisms that underlie the directed migration of epidermal keratinocytes as they populate wounds or in cancer.


        Learning outcomes:



        • The structure and function of matrix adhesion sites (focal contacts and hemidesmosomes) in skin cells (keratinocytes) in  vivo and in vitro.

        • The structural and signaling roles of complexes of hemidesmosome proteins in both adhesion and migration of keratinocytes.

        • The interplay of focal contacts and hemidesmosome protein complexes in the generation of traction forces needed to move a keratinocyte forward.


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