SEP 22, 2020 10:30 AM PDT

Agilent LC-MS Released Glycan Workflow

Speaker
  • Biopharma Business Development Leader
    Biography
      Christopher Colangelo, PhD, MBA is the Agilent Biopharma Business Development Leader for the US and Canada. Prior to joining Agilent, he was the 5th employee and co-inventor of the 454-sequencing platform. In 2003, Chris joined Yale University as a Research Faculty in where he mentored and supervised a research group producing 60+ peer-reviewed publications and directed core research laboratories for four NIH P30 grants, totaling over $21 million worth of research funds.

    Abstract

    The structure of N-linked glycans can play a critical role in the pharmacology of therapeutic proteins, potentially affecting immunogenicity, pharmacokinetics and pharmacodynamics. This makes the characterization of N-glycans an essential part of the biotherapeutic development process. Released glycan mapping is the preferred method used to identify glycosylation sites and total glycan composition. We present Agilent’s comprehensive workflow for N-linked glycan utilizing automated N-linked Glycan sample preparation and high-resolution LC-MS data analysis.


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