FEB 08, 2017 03:00 PM PST

Alternative Delivery Methods for Post-Operative Analgesia Using Meloxicam in Mice

  • Assistant Professor of Small Animal Medicine and Laboratory Animal Medicine
      My research has focused on the pathogenesis of feline immunodeficiency virus (FIV) in cats, and the role of regulatory T cells during the acute phase of FIV infection. More recently, I studied HIV latency and virus reservoirs during anti-retroviral therapy and have developed an interest in studying the role of interferons during acute and chronic retroviral infections. With this experience, I hope to develop clinical trials aimed at improving the management of chronic diseases in companion animals. I am also interested in studies aimed at improving the husbandry and welfare of animals used in research.
    • Associate Director, University Animal Care, University of Arizona
        Dr. Doane has fourteen years of lab animal medicine experience including clinical and surgical medicine, IACUC membership, animal care program administration, and specialty board certification with ACLAM. She is an expert primate veterinarian having served as the Attending Veterinarian and Head of the Division of Animal Resources at the Oregon National Primate Research Center prior to her faculty recruitment to the University of Arizona. In her current role as Associate Director, she oversees three campus vivaria, and the veterinary care of a variety of species including laboratory fish, frogs, rodents, small mammals, cattle, swine, sheep, and NHPs. She is an active member in AALAS both local and national, ASLAP, ACLAM, and has served in numerous board positions including President of APV.


      DATE: February 8, 2017
      TIME: 3:00pm PT, 6:00pm ET

      Meloxicam is an analgesic NSAID commonly used in mice. Anecdotal evidence supports the use of alternative delivery methods for analgesics in food pellets, gel supplements, and injectable sustained release(SR) formulations as ways to achieve long-term analgesia with less frequent handling; potentially minimizing pain and distress. However, objective data comparing the efficacy of these different alternative approaches is lacking in the literature. We conducted a pilot study comparing the efficacy and blood levels of Meloxicam administration by these three alternative delivery methods in a surgical model (osmotic pump placement), using the manufacturer’s recommended dosing. Unfortunately, all three alternative delivery methods failed to deliver adequate pain control at the given doses, suggesting further studies are needed to determine effective dosing for Meloxicam when administered by alternative delivery methods. Here we aim to discuss the challenges of pain control in mice, share our findings with the research community, and determine which (if any) of these alternative dosing methods are currently being used for Meloxicam in research settings.

      Learning Objectives:

      • Describe the most recommended methods for admnistration of Meloxicam in mice
      • Identify three alternative delivery methods for admistration of Meloxicam in mice and discuss their efficacy

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