SEP 16, 2014 9:30 AM PDT

Analysis of Oncomine Knowledgebase to identify NFE2L2 pathway as a novel therapeutic opportunity in multiple cancer types

Speaker
  • Staff Scientist, Bioinformatics, Thermo Fisher Scientific
    Biography
      Dr. Khazanov works as a Bioinformatics Scientist on the Compendia Bioscience™ Translational Bioinformatics Services team, part of Thermo Fisher Scientific. In this role, Dr. Khazanov works with translational scientists to identify potential novel drug targets and to characterize drug-response biomarkers using large sets of data from tumor samples. He earned his doctorate in Bioinformatics from the University of Michigan in 2011, where he worked on structural bioinformatics methods for computational drug design

    Abstract
    Late-stage drug attrition rates in oncology remain higher than in other therapeutic areas. To reduce attrition, it is critical to identify appropriate drug targets and pre-clinical models. The integrative analysis framework was designed to systematically compute associations among driver mutations, fusions and copy alterations to define the driver aberration landscape of common cancers, then correlate the drivers to clinical metadata. Our driver selection methodology was developed through an interrogation of genomic aberrations in a training set of gold standard oncogenes such as EGFR, ALK and PIK3CA, and tumor suppressors such as TP53 and PTEN. The resulting platform was used to rank genes through an assessment of driver genomic aberrations, associations with patient survival, and potential clinical actionability. In this session, Dr. Khazanov will highlight proof of concept identification of a potentially clinically relevant candidate driver gene using a novel systematic integrative analysis of multi-dimensional cancer genomic data.

    Show Resources
    You May Also Like
    JAN 23, 2020 9:00 AM PST
    C.E. CREDITS
    JAN 23, 2020 9:00 AM PST
    DATE: January 23, 2020 TIME: 9:00am PST, 12:00pm EST...
    APR 07, 2020 8:00 AM PDT
    C.E. CREDITS
    APR 07, 2020 8:00 AM PDT
    DATE: April 7, 2020 TIME: 8:00am PT, 11:00am ET This webinar sets out to establish why quality control is key to robust, reliable, reproducible science. We will look at best practice criteri...
    FEB 26, 2020 9:00 AM PST
    C.E. CREDITS
    FEB 26, 2020 9:00 AM PST
    DATE: February 26, 2020 TIME: 9:00am PST 3D cell culture and analysis and the study of organoids and spheroids are becoming more prevalent as a research method in publications as traditional...
    MAY 08, 2020 10:00 AM PDT
    C.E. CREDITS
    MAY 08, 2020 10:00 AM PDT
    DATE: May 8, 2020 TIME: 10:00am PT, 11:00am MT, 1:00pm ET The application of next generation sequencing to interrogate immune repertoires and methods in which these highly complex dataset...
    MAR 31, 2020 9:00 AM PDT
    C.E. CREDITS
    MAR 31, 2020 9:00 AM PDT
    DATE: March 31, 2020 TIME: 9:00am PT, 12:00pm ET HER2-positive breast cancer is a type of breast cancer caused by over-expression of a protein called human epidermal growth factor receptor 2...
    MAR 03, 2020 9:00 AM JST
    C.E. CREDITS
    MAR 03, 2020 9:00 AM JST
    DATE: March 3, 2020 TIME: 9:00am JST A major limitation in the ex vivo expansion of harvested human hematopoietic stem-progenitor cells (HSPCs) is the rapid differentiation of HSPCs at the e...
    Loading Comments...
    Show Resources
    Attendees
    • See more