FEB 07, 2018 1:30 PM PST

Assessment of the Aerodigestive System in Rodents

Speaker
  • Laboratory Animal Resident/Postdoctoral Fellow, University of Missouri

Abstract

The aerodigestive tract is a combination of the respiratory tract and the upper portion of the digestive tract. As these two organ systems share many of the necessary structures used for swallowing, vocalizing, and breathing, they are often studied together as a unit. The lips, tongue, nose, pharynx, larynx, trachea, and esophagus are all examples of structures found within the aerodigestive tract. When there is dysfunction or disease in one system, it often affects the other. As such, dysfunction of the aerodigestive system occurs with a wide range of disorders, including GI motility disorders, reflux disorders, neoplasia, and neurologic diseases such as stroke, Parkinson’s disease, and amyotrophic lateral sclerosis. Symptoms of aerodigestive dysfunction include dysphagia (difficulty swallowing), lung infections due to aspiration, difficulty breathing, hoarseness, halitosis, and/or malnutrition to name a few.  

In order to effectively understand aerodigestive pathology and examine potential therapeutic mechanisms for use in human patients, it is often essential to utilize animal models. Though rodents are commonly used in research, their small size, particularly concerning mice, create various challenges when investigating the complex aerodigestive system. This presentation will discuss several minimally invasive imaging modalities performed in awake or anesthetized rodent models to investigate aerodigestive tract dysfunction and efficacy of various treatments. Specifically, this presentation will cover videofluoroscopic swallow studies and endoscopy of the oral cavity, pharynx, larynx, and/or esophagus. These imaging techniques have been adapted from the standard testing performed in human patients used to diagnose aerodigestive dysfunction and assess treatment efficacy over time. Thus, these imagine modalities serve to increase the translational potential of research involving the upper airway or digestive tract. 


Show Resources
You May Also Like
MAY 08, 2020 10:00 AM PDT
C.E. CREDITS
MAY 08, 2020 10:00 AM PDT
DATE: May 8, 2020 TIME: 10:00am PT, 11:00am MT, 1:00pm ET The application of next generation sequencing to interrogate immune repertoires and methods in which these highly complex dataset...
NOV 10, 2020 7:00 AM PST
Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
NOV 10, 2020 7:00 AM PST
Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
DATE: November 10, 2020 TIME: 7:00am PDT, 10:00am EDT Automation can provide tremendous benefits such as increased pipetting precision and accuracy, productivity, and throughput. Numerous wo...
JUN 09, 2020 10:00 AM PDT
C.E. CREDITS
JUN 09, 2020 10:00 AM PDT
DATE: June 9, 2020 TIME: 10:00am PT, 1:00pm ET The presentation will first discuss sepsis as a disease and then explain the importance of performing diagnostic tests in the clinical labora...
AUG 18, 2020 10:00 AM PDT
C.E. CREDITS
AUG 18, 2020 10:00 AM PDT
DATE: August 18, 2020 TIME: 10:00am PT Get deeper understanding of gene expression patterns by using assays that retain spatial organization at single cell resolution! Come learn about the n...
AUG 25, 2020 8:00 AM PDT
C.E. CREDITS
AUG 25, 2020 8:00 AM PDT
DATE: August 25, 2020 TIME: 8:00am PDT, 10:00am CDT, 11:00am EDT Recombinant lentivirus (LV) and adeno-associated virus (AAV) are critical components of cell and gene therapies, which show g...
OCT 08, 2020 7:00 AM PDT
C.E. CREDITS
OCT 08, 2020 7:00 AM PDT
DATE: October 8, 2020 TIME: 7:00am PDT, 10:00am EDT, 4:00pm CEST How often do you pipette in your cell culture lab every day? Usually, we do it so often that we tend stop thinking about ho...
Loading Comments...
Show Resources
Attendees
  • See more