JAN 30, 2020 9:00 AM PST

An Automated Cancer Organoid Culture Platform to Accelerate Research and Drug Screening

Speaker
  • PhD Candidate at University of Chicago
    Biography
      Brooke completed a BS in Integrative Biology Honors and Chemistry at the University of Illinois Urbana-Champaign (UIUC) in 2014, graduating with high distinction and honors. During her undergraduate career, Brooke's first experience with cell culture was working with equine (horse) stem cells at University of Illinois School of Veterinary Medicine. She even assisted the veterinarians in the tissue and cell collection process. Through this research, she developed her undergraduate honors thesis examining the molecular mechanisms behind osteogenic differentiation for regenerative medicinal applications, leading to her first research publication in Tissue Engineering. Brooke finished her undergraduate career as a member of Dr. Marty Burke's research group, a chemical biology-focused laboratory, and studied the use of certain small molecules as potential synthetic membrane transporters in the context of cystic fibrosis.

      After graduation, Brooke spent time away from academia and worked two years in the medical field, primarily as a clinical research assistant for a medical device start-up company. She traveled the country working with various physicians and medical staff overseeing one of the largest clinical trials for cervical cancer.

      In Fall 2016, Brooke began graduate school as a PhD candidate at The University of Chicago. Soon after, she joined the multidisciplinary team in Savas Tay's laboratory in The University of Chicago's Institute of Molecular Engineering. Brooke's project focused on the development of a microfluidic-based 3D cell culture platform, such as patient-derived cancer organoids, with automated and high-throughput capabilities. She continues to use and develop this integrated platform in hopes to advance the capabilities of research on cancer organoid models, screen and mirror real-life patient chemotherapy treatments and, ultimately, one day facilitate treatment decisions for the development of personalized cancer therapies.

    Abstract
    DATE:  January 30, 2020
    TIME:   9:00am PST, 12:00pm EST
     
    Recent advances in in vitro 3D cellular culture technologies, such as organoids, rapidly developed and established novel, more physiologically relevant models for basic biology and clinical applications. Traditionally, high-throughput microfluidics and other similar technologies have relied on two-dimensional (2D) cell models for the study of various human conditions and diseases, yet they are not compatible with 3D culture. I will discuss the development of an automatic and dynamic microfluidic ex vivo organoid culture modeling system to facilitate and accelerate preclinical research and the development of personalized treatment strategies. This integrated platform combines microfluidics, automatic dynamic and temporal stimulations (ie combinatorial drug screenings), combined with in silico data analysis and prediction tools. The platform can be used to advance the capabilities of research on cancer organoids models, screen and mirror real life patient chemotherapy treatments and ultimately facilitate treatment decisions for the development of personalized therapies.
     
    Learning Objectives:
    • Understand the difference between traditional and microfluidic based cell culture technologies
    • Learn about applying biomedical engineering techniques to advance current 3D cell culture technologies, specifically cancer organoid culture systems 
    • Discover the potential application and capabilities of automatic, high throughput, and dynamic cell culture platforms  
     
    Watch our related webinars here:
     
     
     
    Webinars will be available for unlimited on-demand viewing after live event.
     
    LabRoots is approved as a provider of continuing education programs in the clinical laboratory sciences by the ASCLS P.A.C.E. ® Program. By attending this webinar, you can earn 1 Continuing Education credit once you have viewed the webinar in its entirety.

    Show Resources
    You May Also Like
    MAY 11, 2021 10:00 AM PDT
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    C.E. CREDITS
    MAY 11, 2021 10:00 AM PDT
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    Date: May 11, 2021 Time: 10:00zm PDT Your samples are some of the most valuable assets in the laboratory. After spending countless hours on extraction and preparation, your conclusions could...
    JUN 09, 2021 7:00 AM PDT
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    C.E. CREDITS
    JUN 09, 2021 7:00 AM PDT
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    Date: June 9, 2021 Time: 09 June 2021, 7am PDT, 10am EDT, 4pm CEST cells with dramatic implications on the validity of past cell culture related research. The fact that at least 509 cell lin...
    DEC 02, 2020 8:00 AM PST
    C.E. CREDITS
    DEC 02, 2020 8:00 AM PST
    DATE: December 2nd, 2020 TIME: 08:00am PDT, 11:00pm EDT Bioreactors and shakers are used to cultivate microorganisms, plant, insect, and mammalian cells in different volumes. Upscaling of pr...
    NOV 18, 2020 8:00 AM PST
    C.E. CREDITS
    NOV 18, 2020 8:00 AM PST
    DATE: November 18, 2020 TIME: 08:00am PDT We develop and implement technologies to solve some of the major bottlenecks in biomedical research. In particular, we establish new imaging approac...
    OCT 29, 2020 6:00 AM PDT
    C.E. CREDITS
    OCT 29, 2020 6:00 AM PDT
    Date: October 29, 2020 Time: 6:00am (PDT), 9:00am (EDT), Chronic inflammation can occur as a result of a combination of genetic predispositions and environmental factors. Epigenetic modifica...
    NOV 16, 2020 8:00 AM PST
    C.E. CREDITS
    NOV 16, 2020 8:00 AM PST
    Date: November 16, 2020 Time: 8:00am (PST), 11:00am (EST) CRISPR screening has become the prime discovery tool in modern biomedical research and drug discovery. At the same time, most screen...
    JAN 30, 2020 9:00 AM PST

    An Automated Cancer Organoid Culture Platform to Accelerate Research and Drug Screening


    Specialty

    Cancer Research

    Cell Biology

    Molecular Biology

    Cell Culture

    Immunology

    Cancer Therapeutics

    Biotechnology

    Biomarkers

    Cancer Diagnostics

    Molecular Diagnostics

    Genetics

    Oncology

    Drug Discovery

    Clinical Research

    Biochemistry

    Geography

    North America56%

    Europe21%

    Asia15%

    South America5%

    Africa2%

    Oceania1%

    Registration Source

    Email Promotions42%

    Website Visitors41%

    WAVE Newsletter Promotion7%

    Trending Newsletter Promotion2%

    Website Banners1%

    Other7%

    Job Title

    Research Scientist18%

    Student15%

    Scientist10%

    Executive9%

    Medical Laboratory Technician9%

    Educator/Faculty9%

    Facility/Department Manager8%

    Clinical Laboratory Scientist5%

    Medical Doctor/Specialist5%

    Post Doc5%

    Lab Management4%

    Marketing/Sales2%

    Biologist2%

    Organization

    Academic Institution32%

    Biotech Company10%

    Hospital9%

    Research Institute9%

    Clinical Laboratory6%

    Government5%

    Pharmaceutical Company5%

    Life Science Company3%

    Medical School3%

    Medical Center2%

    Non-Profit Organization2%

    Contract Research Organization (Cro)1%

    Ambulatory Care1%

    Consultant1%

    Other2%


    Show Resources
    Loading Comments...
    Show Resources
    Attendees
    • See more