FEB 27, 2019 3:00 PM PST

BASKET Trials: Biomarker Driven Drug Development

Presented at: Drug Discovery 2019
Speaker
  • Professor of Medicine (Oncology) and of Radiology (Molecular Imaging Program at Stanford), Director Phase I Clinical Research, Director, Translational Oncology Program, Stanford University
    BIOGRAPHY

Abstract

Dramatic responses observed with targeted agents in the ‘right’ genomic context have fueled large scale sequencing efforts to identify ‘effective’ treatments for a given patient. In order to expeditiously evaluate a targeted agent against a potential ‘driver’ genetic aberration, so-called Basket trials are conducted. Basket trials enroll patients with multiple tumor types that carry a common genetic aberration and evaluate a single targeted treatment regimen. I will discuss the rationale, design, and challenges in conducting Basket trials.

Learning Objectives:

1. Learn about when to consider conducting a Basket trial and how to design it
2. Learn about the promises and challenges of identifying patients based on genomic aberrations
 


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FEB 27, 2019 3:00 PM PST

BASKET Trials: Biomarker Driven Drug Development

Presented at: Drug Discovery 2019


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