OCT 11, 2017 06:00 AM PDT

Cancer Chemotherapy and the tools needed to Advance Treatment in a Diverse Racial Population

C.E. CREDITS: P.A.C.E. CE | Florida CE
Speakers
  • Associate Professor, Department of Family, Population & Preventive Medicine, Stony Brook School of Medicine
    Biography
      Dr. Williams is an Associate Professor at Stony Brook University with a primary appointment in the Department of Family, Population, and Preventive Medicine and a secondary appointment in the Department of Medicine. She is Assistant Dean for Student Diversity where she serves as the primary liaison between Stony Brook Medicine and Stony Brook University, acting to encourage diverse undergraduate and graduate students to seek out and succeed in careers in the health sciences. Dr. Williams is also an affiliate faculty member in the Institute for STEM Education where she works with underrepresented community college students who are interested in biomedical careers.

      Dr. Williams has investigated the use of gene therapy in the prevention of AIDS and done extensive work on the effectiveness of non-steroidal anti-inflammatory drugs (NSAIDS), NO-releasing-NSAIDs (NO-NSAIDS), and other pharmacological agents on stemming the progression of cancer. In this capacity, she is defining the mechanistic role of NF-κB and other transcriptional factors in colon cancer prevention in response to novel chemo-therapeutic/-preventive agents. Currently, she is addressing the underlying genetic/regulatory causes associated with cancer racial health disparity. As such, Dr. Williams' group is assessing the dysregulation of miRNAs and aberrant DNA methylation as factors influencing racial health disparity in the incidence and mortality rates of colorectal cancer.

      Dr. Williams earned her BS from Savannah State University, an MS from Tuskegee University, and a PhD in molecular biology at Purdue University. She completed a postdoctoral fellowship in infectious diseases at Harvard University and conducted postdoctoral work at the New England Regional Primate Research Center's Department of Immunology and the American Health Foundation. Dr. Williams then joined Harvard University as a research scientist and was later recruited to Stony Brook as a Research Assistant Professor, being promoted to Associate Professor with tenure in 2013.

    Abstract:

    Colorectal  cancer  (CRC)  is  the  third  most  commonly  diagnosed  cancer  and  is  the  third leading  cause of  cancer-related deaths in the western world.  The mortality from colorectal cancer in Caucasian American (CAs) has been declining, but the death rate continues to be higher in African Americans (AAs), maintaining the racial disparity. In addition, AAs more often present with CRC at advanced stages contributing to the lower five year survival rate. Hispanic-Americans (HAs) have significantly lower CRC incidence and mortality rates when compared with Non- Hispanic AA (NH-AA) and Non-Hispanic CA (NH- CA) populations. However, rates among HAs are significantly higher than those among residents of Puerto Rico and other Spanish-speaking countries in South and Central America. Furthermore, preliminary data and documented results show that for HA the age at presentation is lower and the stage of the disease is higher than that of AA and CAs. We hypothesize that various factors (i.e., familial, socioeconomic, environmental and dietary) may contribute to the underlying problem of colon cancer racial/ethnic health disparity. Also, it has been noted that the response to chemopreventive agents differ as to the biological/genetic heterogeneity of the tumors of NH-AAs, HAs and NH-CAs. Since chemopreventive agents exert their effect through a molecular target, this disparity would suggest differences at the genetic level. Therefore, the formulation and evaluation of chemopreventive/chemotherapeutic agents that address the issue of differential chemoresponse and chemoresistance is essential to survival. To study, in vitro and in vivo, the development of and chemo-responsiveness of therapeutic agents to colonic diseases in diverse populations, the availability of the appropriate cells (cell lines/organoids) and animal (PDX) models are critical. Our overarching goal is to assess racial and ethnic genetic/epigenetic dysregulations and associate these changes to chemoresponse and colon cancer racial disparity. The availability of these biological tools will facilitate overcoming differential incidence and outcome seen among racial and ethnic groups for CRC. To achieve this goal, we are generating and characterizing novel cell lines, PDXs and organoids derived from NH-CAs, HAs and AAs patients with colorectal cancer. Downstream use of these biological tools will assist our group and the scientific community at large in improving targeted personal cancer treatment. This research effort is inclusive of all and will benefit a diverse population. 


    Show Resources
    You May Also Like
    SEP 05, 2019 04:00 PM CEST
    C.E. CREDITS
    SEP 05, 2019 04:00 PM CEST
    DATE: September 5, 2019TIME: 7:00am PT, 10:00am ET, 4:00pm CEST PCR (Polymerase Chain Reaction) has gone through a massive evolution since its development in 1983. Besides it...
    JUN 05, 2019 05:00 PM CEST
    C.E. CREDITS
    JUN 05, 2019 05:00 PM CEST
    DATE: June 5, 2019TIME: 8:00am PDT, 11:00am EDT, 5:00pm CEST Eukaryotic cell cultures respond to the most subtle influence. Apart from the risk of contamination, minimal chan...
    AUG 27, 2019 09:00 AM PDT
    C.E. CREDITS
    AUG 27, 2019 09:00 AM PDT
    DATE: August 27, 2019 TIME: 9:00am PDT, 12:00pm EDT Immunotherapies targeting PD-1 or PD-L1 have proven remarkably effective for treating cancer in some patients, with considerabl...
    MAY 16, 2019 04:00 PM CEST
    C.E. CREDITS
    MAY 16, 2019 04:00 PM CEST
    DATE: May 16, 2019TIME: 7:00am PDT, 10:00am EDT, 4:00pm CEST The emergence of NGS is revolutionizing the microbiological sciences and transforming medicine. Deep sequencing has...
    JUN 19, 2019 10:00 AM PDT
    JUN 19, 2019 10:00 AM PDT
    DATE: June 19, 2019TIME: 10:00am PDT, 1:00pm EDT As we develop new methods to create more biologically relevant models for research in understanding disease etiology and in...
    OCT 02, 2019 11:00 AM PDT
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    OCT 02, 2019 11:00 AM PDT
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    DATE: October 2, 2019TIME: 11:00am PDT, 2:00pm EDT Ditch the Excel spreadsheets and manage your molecular workflows entirely in your LIMS Achieve configuration of molecular workf...
    Loading Comments...
    Show Resources