MAR 16, 2017 9:00 AM PDT

Capturing cocaine memories in the perineuronal net

Speaker

Abstract

Specialized aggregations of extracellular matrix called perineuronal nets (PNNs) appear during juvenile stages of development and surround primarily fast-spiking, parvalbumin (PV)-containing GABAergic interneurons in the central nervous system. These PNNs are an exciting structure to explore in drug abuse research because previous studies show that removing them in certain brain regions re-establishes juvenile-like states of plasticity; therefore, we may be able to alter the brain plasticity imposed by drugs of abuse. Our studies in rats show that removal of PNNs within the prelimbic region of the medial prefrontal cortex (mPFC) impairs the consolidation and reconsolidation of cocaine-associated memories in a cocaine-induced conditioned place preference (CPP) task. In addition, removal of PNNs blunts the acquisition of cocaine self-administration and appears to blunt the reconsolidation of the memory associated with cocaine cues. Conversely, cocaine exposure alters the intensity (thickness) of PNNs and the intensity of PV cells in the prelimbic mPFC. While acute cocaine injection decreases the intensity of PNNs and PV cells, repeated cocaine injection increases the intensity of PNNs and PV cells. Some of these changes observed after cocaine may be mediated by oxidative stress. Overall, our studies suggest that PNNs within the mPFC are highly dynamic and modulate cocaine-induced plasticity.


Show Resources
You May Also Like
FEB 15, 2023 7:00 AM PST
FEB 15, 2023 7:00 AM PST
Date: February 15, 2023 Time: 7:00am (PST), 10:00pm (EST), 4:00pm (CET) While not all microscopy samples can fluoresce, all can scatter light, and this scattered light can be imaged. This ha...
NOV 16, 2022 7:00 PM PST
C.E. CREDITS
NOV 16, 2022 7:00 PM PST
Date: November 16, 2022 Time: 2:00pm (AEST) Date: November 17, 2022 7:00pm (PST), 10:00pm (EST), 4:00am (CET) The growth in FDA-approved cell and gene therapy products for the treatment of d...
AUG 24, 2022 7:00 AM PDT
AUG 24, 2022 7:00 AM PDT
Date: August 24, 2022 Time: 7:00am (PDT), 10:00pm (EDT), 4:00pm (CEST) Light field microscopy was first introduced in 2006, and allows users to capture the 4D light field within the microsco...
SEP 22, 2022 9:00 AM PDT
SEP 22, 2022 9:00 AM PDT
Date: September 22, 2022 Time: 9:00am (PDT), 12:00pm (EDT), 6:00pm (CEST) Optimizing platforms for surgical specimen collection and deep human phenotyping was used to enhance protein biomarke...
DEC 15, 2022 8:00 AM PST
DEC 15, 2022 8:00 AM PST
Date: October 26, 2022 Time: 9:00am (PST), 12:00pm (EST), 6:00pm (CEST) Current protein biomarkers are only moderately predictive in identifying individuals with mild traumatic brain injury...
JAN 25, 2023 10:00 AM PST
JAN 25, 2023 10:00 AM PST
Date: January 25, 2023 Time: 10:00am (PST), 1:00pm (EST), 7:00pm (CET) The field of proteomics is poised for a single-molecule revolution – enabling more comprehensive analysis of the...
MAR 16, 2017 9:00 AM PDT

Capturing cocaine memories in the perineuronal net



Show Resources
Loading Comments...
Show Resources
Attendees