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DEC 15, 2016 7:00 AM PST

Characterization and affinity maturation of TCRmimic scFvs identified using phage display

Sponsored by: Abcam
Speaker
  • MD-PhD candidate, Johns Hopkins School of Medicine
    Biography
      Jackie Douglass completed bachelors' degrees in Chemical-Biological Engineering and Economics and a master's degree in Chemical Engineering Practice at MIT. She is currently an MD-PhD candidate at Johns Hopkins School of Medicine and is doing her PhD thesis in the lab of Bert Vogelstein.

      Her thesis involves using phage display to identify TCRmimic scFvs (antibody fragments) recognizing mutant peptide-HLA complexes and translating these scFvs into therapeutic formats.

    Abstract

    DATE: December 15, 2016
    TIME: 7:00am PT, 10:00am ET, 3:00pm London, 4:00pm CET

    Phage display is an increasingly popular, robust, and rapid method of antibody identification, particularly for antigens not amenable to antibody discovery using traditional hybridoma technology. 

    During this session, we will review:

    • Identification of scFv antibody fragments using phage display
    • Expression, affinity maturation, and characterization of scFvs 

    Register today to hear more about this exciting topic, and have your questions answered during a live Q&A session!

    Learning Objectives:

    • Learn about a potential strategy for targeting neo-antigens for cancer therapies
    • Learn one use of phage display technology for developing therapeutic agents against cancer

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