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FEB 26, 2020 12:00 PM PST

Characterizing the role of B cells in Response to Immunotherapy with the NanoString GeoMx Platform

Sponsored by: NanoString Technologies
C.E. Credits: P.A.C.E. CE Florida CE
Speaker
  • Senior Director of Advanced Applications, NanoString Technologies
    Biography
      Sarah Warren is the Senior Director of Translational Science at NanoString Technologies where she leverages multiplexed, molecular profiling technologies to address key research areas in oncology, immunology, and beyond. Her role enables her to work with academics, biopharmas, and clinicians to identify unmet needs in translational research and create novel products for transcriptional and proteomic profiling. She is also active in the immuno-oncology research community to promote the science and application of cancer immunotherapy to improve patient outcomes. Prior to joining NanoString, she was a founder and director of research at Oncofactor Corp., a biotech startup focused on developing therapeutics which targeted novel immune checkpoints. She has a PhD in immunology from the University of Washington and performed her graduate work at the Institute for Systems Biology.

    Abstract

    Digital spatial profiling (DSP) on the NanoString GeoMx platform enables high plex molecular profiling of clinical tissue samples. This new profiling strategy enables deep insights into the heterogenous nature of gene and protein expression as it is driven by the distribution and colocalization of cells within a tissue. Recently, DSP was featured in 2 back to back Nature publications elucidating the important role of B cells in mediated immune response to immunotherapy in melanoma. These studies, from the laboratories of Dr. Jennifer Wargo at the MD Anderson Cancer Center and Dr. Goran Jonsson at Lund University, leverage DSP as well as other traditional and next generation profiling strategies to deeply characterize the molecular expression patterns and spatial architecture of the key immune populations within tertiary lymphoid structures in the tumor. Dr. Sarah Warren will speak about both of these publications, as well as how the work was enabled by prior DSP profiling of melanoma samples from Dr. Wargo’s lab. This webinar will present an overview of the GeoMx platform as well as demonstrate its application to current clinically impactful questions in immuno-oncology.

    Learning Objectives:
    1. Understand the biology around B cells and tertiary lymphoid structures in cancer
    2. Understand how spatial high plex profiling was used to characterize immune responses within melanoma


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