Clinical whole genome sequencing (cWGS) is rapidly gaining acceptance as cost is decreasing and success rates in identifying disease-causing variants are increasing. While the application of genomics in healthcare has historically centered around diagnosis of disease, the desire to apply genomics to risk assessment and disease prevention is growing. In the context of an educational program called Understand Your Genome, Illumina has offered cWGS in an ostensibly healthy population since 2012. To date, more than 1300 adults have been sequenced as part of this program, which has generated data about the motivations of this population, what medical findings can be seen in a generally healthy adult population and the value of genome sequencing over time.
Learning Objective 1: Analyze the benefits of sequencing a healthy population, for the individual and for the contribution to genomics knowledge
Learning Objective 2: Identify the frequency of findings expected to be of clinical significance in a healthy adult