OCT 22, 2020 12:25 PM PDT

Clinical impact of Next-Generation Sequencing (NGS) Testing: A hematopathologist's perspective

C.E. Credits: P.A.C.E. CE Florida CE
Speaker
  • Director of the Division of Hematopathology, Hospital of the University of Pennsylvania
    Biography

      Megan S. Lim, MD, PhD is the Director of the Division of Hematopathology, Hospital of the University of Pennsylvania, Director of the Hematopathology Fellowship Program, and the Director of the Lymphoma Biology Program at the Abramson Cancer Center. She is a Professor within the Department of Pathology and Laboratory Medicine, Dr. Lim received an MD from the University of Calgary and a PhD in Molecular Oncology from the University of Calgary and National Cancer Institute Lab of Pathology jointly. Dr. Lim obtained her Hematopathology fellowship training at the National Cancer Institute after which she assumed a faculty position at the University of Toronto (1998-2000), the University of Utah (2000-2006). the University of Michigan (2006-2015) before moving to the University of Pennsylvania in 2015. Dr. Lim is certified by the American Board of Pathology in Anatomic Pathology, with subspecialty certification in Hematopathology and Molecular Genetic Pathology.  She has held numerous leadership positions and served on training and education committees for the Association of Molecular Pathology and the United States Academy of Pathology. She is a member of the Board of Directors for the United States Academy of Pathology. She is the Vice-Chair of the Non-Hodgkin Lymphoma Disease Committee of the Children's Oncology Group and participates in integrated translational research in pediatric lymphoma. Her research interests are focused on elucidating mechanisms involved in lymphoma pathogenesis which are supported by the NIH. She has participated and directed numerous CME activities for AMP, ASCP, CAP, and the USCAP.


    Abstract

    Myeloid neoplasms represent a highly heterogeneous group of diseases that encompass myeloproliferative, myelodysplastic (myeloproliferative/myelodysplastic) processes and acute myeloid leukemias. The diagnostic workup of patients with suspected myeloid neoplasms is labor-intensive and operationally complex requiring coordination of multiple clinical and laboratory personnel, resources and requires integration of highly fragmented results. In this presentation, we will discuss the hematopathologist’s perspective on the clinical impact of recent advancements in NGS testing.

    Learning Objectives:
    1. Understand the contribution of genetic abnormalities in the diagnostic workup of patients with suspected myeloid neoplasms
    2. Recognize the limitations of current diagnostic workflow in providing timely integrated genomic results for patients with suspected myeloid neoplasms
    3. Become familiar with clinical scenarios where rapid integrated NGS may facilitate diagnostic workup of patients with suspected hematologic malignancies


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