OCT 24, 2019 9:00 AM PDT

A Comparison of Established NMR Chemometric Methods in Biopharma

C.E. Credits: P.A.C.E. CE Florida CE
Speaker
  • Research Chemist, National Institute of Standards and Technology, Institute for Bioscience and Biotechnology Research
    BIOGRAPHY

Abstract

Therapeutic monoclonal antibodies are a clinically important and life-saving class of biotherapeutics used in the treatment of several previously intractable diseases. However, their development and manufacture presents many significant analytical challenges. The characterization of higher order structure (HOS) is of critical importance, since misfolding or aggregation of a biotherapeutic can lead to loss of efficacy or elicit unintended immune responses. NMR spectroscopy is well suited for such characterization given the ability to detect subtle changes in HOS. Here, we report a combined interlaboratory analysis of 1D and 2D methyl techniques, using linear correlation methods on a panel of mAb samples. Results suggest that the techniques are complimentary to each other, and are reproducible regardless of operator, laboratory and spectrometer field strength.


Show Resources
You May Also Like
MAY 11, 2021 10:00 AM PDT
C.E. CREDITS
MAY 11, 2021 10:00 AM PDT
Date: May 11, 2021 Time: 10:00zm PDT Your samples are some of the most valuable assets in the laboratory. After spending countless hours on extraction and preparation, your conclusions could...
APR 01, 2021 8:00 AM PDT
C.E. CREDITS
APR 01, 2021 8:00 AM PDT
Date: April 01, 2021 Time: 8:00am (PST), 11:00am (EST) Generating therapeutic antibodies is far more challenging than obtaining antibodies that merely recognize their targets. Engineering po...
APR 20, 2021 11:00 AM PDT
C.E. CREDITS
APR 20, 2021 11:00 AM PDT
Date: April 20, 2021 Time: 11:00am (PST), 2:00pm (EST) Identification and confirmation of microbial isolates is crucial in the analysis workflow, providing decision-makers the information...
MAR 16, 2021 10:00 AM PDT
C.E. CREDITS
MAR 16, 2021 10:00 AM PDT
Date: March 16, 2021 Time: 10:00am (PST) Scientific progress and breakthroughs today are often too expensive for most institutions to acquire. Each year, the National Institutes of Health (N...
APR 19, 2021 8:00 AM PDT
C.E. CREDITS
APR 19, 2021 8:00 AM PDT
Date: Apri 19, 2021 Time: 8:00am PDT, 5:00pm CEST Since the inception of modern biological research, BioSafety has evolved into a critical consideration in Good Laboratory Practices (GLP). Wi...
APR 20, 2021 7:00 AM PDT
APR 20, 2021 7:00 AM PDT
Date: April 20, 2021 Time: 7:00am (PDT), 10:00am (EST) There is a vital need to characterize Biopharmaceuticals in early phase screening to ensure the most suitable candidates are accelerate...
OCT 24, 2019 9:00 AM PDT

A Comparison of Established NMR Chemometric Methods in Biopharma

C.E. Credits: P.A.C.E. CE Florida CE

Specialty

Microbiology

Laboratory Testing

Dna

Research

Biotechnology

Molecular Biology

Cancer Diagnostics

Clinical Diagnostics

University

Research And Development

Genomics

Cancer Therapeutics

Pcr/rt-Pcr/real-Time Pcr

Animal Research

T-Cells

Geography

Asia50%

North America33%

South America8%

Africa8%

Registration Source

Website Visitors92%

Email Promotions8%

Job Title

Medical Laboratory Technician27%

Educator/Faculty27%

Student9%

Medical Doctor/Specialist9%

Research Scientist9%

Engineer9%

Chemist9%

Organization

Academic Institution42%

Clinical Laboratory17%

Manufacturer - Other17%

Hospital8%

Diagnostic Company8%

Other8%


Show Resources
Loading Comments...
Show Resources
Attendees
  • See more