AUG 21, 2013 2:00 PM PDT

Comprehensive Chromosome Screening in the Human Embryo

C.E. Credits: CE
Speaker
  • Director of Molecular BiologyResearch, Reproductive Medicine Associatesof New Jersey, Associate Professor, Department of Obstetrics, Gynecology,and Reproductive Sciences, UMDNJ-Robert Wood Jo
    Biography
      Dr. Nathan Treff serves as Director of Molecular Biology Research at RMA of New Jersey, Associate Professor at the Robert Wood Johnson Medical School, and Adjunct Professor at Rutgers University. Dr. Treff's laboratory uses molecular genetics to discover, develop, and translate novel molecular diagnostics to improve the quality of life for patients with infertility and has published more on the use of arrays in preimplantation aneuploidy screening than any other group in the world. His research was awarded the 2007 and 2010 General Program Prize and the 2009 and 2010 Society for Assisted Reproductive Technology Prize by the American Society for Reproductive Medicine. He completed his Ph.D. in biochemistry at Washington State University where he earned the Charles Glenn King Scholarship and the National Institutes of Health Predoctoral Fellowship in protein biotechnology. Dr. Treff trained as a postdoctoral fellow in stem cell biology at the University of Wisconsin-Madison, and in reproductive biology at the EMD-Serono Research Institute.

    Abstract

    The human species is particularly prone to chromosome segregation errors during maternal meiosis in the egg and during post zygotic mitosis in the preimplantation embryo. In fact, aneuploidy represents the most common genetic abnormality in humans, and is the primary cause of infertility, affecting 1 in 6 couples. Despite the extremely limited amount of DNA available from a human embryo, development of genetic technologies, such as qPCR and next generation sequencing, now allow accurate and effective analysis of the copy number of all 24 chromosomes in preimplantation stage human embryos produced during in vitro fertilization (IVF). Selection of chromosomally normal embryos improves the efficacy of single embryo transfer, eliminating the primary complication of IVF (multiple gestations), and improves the success of treating infertility. This presentation will detail the development, validation, and future directions of new human embryo comprehensive chromosome screening technologies.


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