AUG 27, 2019 8:00 AM PDT

Comprehensive Proteomics and Lipidomics Strategies to Advance Disparities Research in Alzheimer's Disease

Sponsored by: Agilent
C.E. Credits: P.A.C.E. CE Florida CE
Speaker
  • Associate Professor of Chemistry, Vanderbilt University
    Biography
      Dr. Renã Robinson received her B.S. in Chemistry with a concentration in Business from the University of Louisville in 2000 and her Ph.D. in Analytical Chemistry from Indiana University in 2007 under the mentorship of Professor David Clemmer. During her graduate studies she developed proteomics methods to study aging in Drosophila (fruit flies) and continued her work in aging a Lyman T. Johnson Postdoctoral Fellow with Professor D. Allan Butterfield in the department of Chemistry at the University of Kentucky. During this fellowship she began to focus on neurodegenerative disorders such as Alzheimer's disease and received a UNCF/Merck Postdoctoral Fellowship. Dr. Robinson joined the Department of Chemistry at the University of Pittsburgh as an Assistant Professor in 2009 until her recent move to Vanderbilt in the summer of 2017 where she serves as an Associate Professor of Chemistry and the Dorothy J. Wingfield Phillips Chancellor's Faculty Fellow.
      Dr. Robinson has a nationally and internationally recognized research program and she is as an emerging leader in the field of proteomics for her work in aging, Alzheimer's disease and applications relevant to human health and disparities. Chemical and Engineering News awarded her with the 2016 Talented Twelve Award, distinguishing her as one of the world's brightest young minds in the field of chemistry. She is also the recipient of several awards including a Starter Grant Award from the Society for Analytical Chemistry of Pittsburgh, the 2014 Lloyd N. Ferguson Young Scientist Award from NOBCChE (The National Organization of Black Chemists and Chemical Engineers), and the 2017 Pittsburgh Conference Achievement Award. She currently serves as an Executive Board Member for NOBCChE and is an active member of several societies across the fields of chemistry, mass spectrometry, proteomics, and Alzheimer's disease.

    Abstract

    DATE: August 27, 2019
    TIME: 08:00 AM PDT 


    Our laboratory is exploring hypotheses about how lipid metabolism contributes to racial disparities in Alzheimer’s disease using comprehensive proteomics and lipidomics mass spectrometry-based approaches. Specifically, we have developed robust quantitative assays to measure proteins in post-mortem brain, liver, and heart tissue as well as in plasma and a range of lipids and lipid classes in plasma. Combined, these analyses provide tremendous insight into lipid metabolism and many other biological pathways that are altered in the brain and periphery of Alzheimer’s disease. Furthermore, protein and lipid changes that are altered in ways that are unique to a given racial/ethnic background have been assessed. This presentation will discuss the various proteomic and lipidomics approaches established, results from pilots with small cohorts of Alzheimer’s disease patients, and the implications of these findings for understanding disease pathogenesis especially as it relates to racial/ethnic disparities in Alzheimer’s disease.
     
    Learning objectives:

    • Participants will learn about the relationship between lipid metabolism and racial disparities in Alzheimer’s disease.
    • Participants will learn quantitative proteomics strategies for assessing differences in various biological tissues from diseased and control individuals.
    • Participants will learn mass spectrometry based lipidomics strategies to profile lipids in human plasma.

     

    For Research Use Only. Not for use in diagnostic procedures.

     

    Webinars will be available for unlimited on-demand viewing after live event.
     
    LabRoots is approved as a provider of continuing education programs in the clinical laboratory sciences by the ASCLS P.A.C.E. ® Program. By attending this webinar, you can earn 1 Continuing Education credit once you have viewed the webinar in its entirety.

     


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