DATE: August 27, 2019
TIME: 08:00 AM PDT
Our laboratory is exploring hypotheses about how lipid metabolism contributes to racial disparities in Alzheimer’s disease using comprehensive proteomics and lipidomics mass spectrometry-based approaches. Specifically, we have developed robust quantitative assays to measure proteins in post-mortem brain, liver, and heart tissue as well as in plasma and a range of lipids and lipid classes in plasma. Combined, these analyses provide tremendous insight into lipid metabolism and many other biological pathways that are altered in the brain and periphery of Alzheimer’s disease. Furthermore, protein and lipid changes that are altered in ways that are unique to a given racial/ethnic background have been assessed. This presentation will discuss the various proteomic and lipidomics approaches established, results from pilots with small cohorts of Alzheimer’s disease patients, and the implications of these findings for understanding disease pathogenesis especially as it relates to racial/ethnic disparities in Alzheimer’s disease.
For Research Use Only. Not for use in diagnostic procedures.
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