AUG 01, 2023 9:00 AM PDT

Current Status of Detecting Moncolonal Antibodies and Free Light Chains in Serum

Sponsored by: Sebia, Inc.
C.E. Credits: P.A.C.E. CE Florida CE
  • Matthias Orth, MD, PhD

    Director, Institute for Laboratory Medicine, Marienhospital Stuttgart & Lecturer, University of Heidelberg, Medical Faculty of Mannheim

Event Date & Time
Date: August 1, 2023
Time: 9:00 AM (PDT), 12:00 PM (EDT), 6:00 PM (CEST)
Testing for abnormal immunoglobulins was based previously on serum electrophoresis and immunofixation only. In the last years, however, free light chain (FLC) testing in serum became one important pillar in the diagnosis and monitoring of multiple myeloma and related disorders such as amyloidosis, most of these diseases occurring in older patients. In particular, the ratio of κ FLCs to λ FLCs became pivotal in the diagnosis, monitoring, and rule-out of patients with suspected myeloma. The challenge of this serum testing is the heterogeneity of free light chains and other methodical issues of testing which challenge in particular FLC tests based on turbidimetry and nephelometry. The other challenges arise from the accumulation of FLC in serum due to the impaired excretion of FLC in patients with altered renal function - and renal function will decrease with age physiologically. Since elevated FLC will damage the kidneys, the establishment of reference ranges is challenging, and adequate reference ranges are necessary to obtain good discrimination between patients and normal („healthy“) subjects. This webinar will describe the laboratory tests currently used and will suggest methods to establish reference ranges that allow the optimized use of FLC assays.
Learning Objectives
  • Describe the methodical challenges of FLC testing
  • List the challenges of obtaining reference ranges for FLC testing
  • Compare the role of SPE, immunofixation/immunotyping, serum FLC assays, and urine tests for diagnosing and for monitoring
Webinars will be available for unlimited on-demand viewing after live event.
Labroots is approved as a provider of continuing education programs in the clinical laboratory sciences by the ASCLS P.A.C.E. ® Program. By attending this webinar, you can earn 1 Continuing Education credit once you have viewed the webinar in its entirety.

You May Also Like
Loading Comments...